{"doi":"10.1128/jvi.01725-21","title":"Vaccine-Associated Enhanced Respiratory Disease following Influenza Virus Infection in Ferrets Recapitulates the Model in Pigs","abstract":"We demonstrated the susceptibility of ferrets, a laboratory model species for human influenza A virus research, to vaccine-associated enhanced respiratory disease (VAERD) using an experimental model previously demonstrated in pigs. Ferrets developed clinical characteristics of VAERD very similar to that in pigs. The hemagglutinin (HA) stalk is a potential vaccine target to develop more efficacious, broadly reactive influenza vaccine platforms and strategies. However, non-neutralizing antibodies directed toward a conserved epitope on the HA stalk induced by an oil-in-water, adjuvanted, whole influenza virus vaccine were previously shown in VAERD-affected pigs and were also identified here in VAERD-affected ferrets. The induction of VAERD in ferrets highlights the potential risk of mismatched influenza vaccines for humans and the need to consider VAERD when designing and evaluating vaccine strategies.","journal":"Journal of Virology","year":2022,"id":252286,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9621,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":896751,"name":"Meghan Wymore Brand","orcid":null,"position":1,"is_corresponding":false},{"id":499698,"name":"Bryan S. Kaplan","orcid":"0000-0003-4077-0571","position":2,"is_corresponding":false},{"id":499701,"name":"Phillip C. Gauger","orcid":"0000-0003-2540-8769","position":3,"is_corresponding":false},{"id":438475,"name":"Elizabeth M. Coyle","orcid":null,"position":4,"is_corresponding":false},{"id":896752,"name":"Katarina Chilcote","orcid":null,"position":5,"is_corresponding":false},{"id":437341,"name":"Surender Khurana","orcid":"0000-0002-0593-7965","position":6,"is_corresponding":false},{"id":896342,"name":"Amy L. Vincent","orcid":"0000-0002-4953-7285","position":7,"is_corresponding":false},{"id":499699,"name":"J. Brian Kimble","orcid":"0000-0003-1245-1530","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T00:24:46.226372Z","pmid":"34985999","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}