{"doi":"10.1128/jvi.01654-20","title":"Membrane-Associated and Secreted Forms of the Rhesus Macaque Rhadinovirus-Encoded CD200 Homologue and Cellular CD200 Demonstrate Differential Effects on Rhesus Macaque CD200 Receptor Signaling and Regulation of Myeloid Cell Activation","abstract":"studies of RRV vCD200 have utilized an Fc fusion protein to examine functionality, which does not replicate the structural properties of the membrane-associated form of vCD200 that is naturally produced during RRV infection. In this study, we demonstrate for the first time that membrane-expressed RRV vCD200 is capable of inducing signal transduction via RM CD200R, while the secreted form of vCD200 appears to be non-functional. Further, we also demonstrate that RM CD200 induces signaling via RM CD200R, and is more robust than RRV vCD200, while KSHV vCD200 does not appear to induce efficient signaling via RM CD200R.","journal":"Journal of Virology","year":2020,"id":131929,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9473,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":535670,"name":"Aparna Govindan","orcid":null,"position":1,"is_corresponding":false},{"id":586796,"name":"Kristin Fitzpatrick","orcid":"0000-0001-8086-5239","position":2,"is_corresponding":false},{"id":490831,"name":"Tiffany C. Blair","orcid":"0000-0002-9136-4736","position":3,"is_corresponding":false},{"id":586797,"name":"Seyed Abdolrahim Rezaee","orcid":"0000-0001-6814-5992","position":4,"is_corresponding":false},{"id":539421,"name":"David J. Blackbourn","orcid":"0000-0002-6703-4497","position":5,"is_corresponding":false},{"id":459584,"name":"Scott W. Wong","orcid":"0000-0001-6855-0808","position":6,"is_corresponding":false},{"id":534847,"name":"Ryan D. Estep","orcid":"0000-0001-7785-8564","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-18T23:16:07.542484Z","pmid":"33328302","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}