{"doi":"10.1128/jvi.01560-20","title":"Orsay Virus CP-δ Adopts a Novel β-Bracelet Structural Fold and Incorporates into Virions as a Head Fiber","abstract":"Viruses often have extended fibers to mediate host cell recognition and entry, serving as promising targets for antiviral drug development. Unlike other known viral fibers, the δ proteins from the three recently discovered nematode viruses are incorporated into infectious particles as protruding fibers covalently linked to the capsid. Crystal structures of δ revealed novel pentameric folding repeats, which we term β-bracelets, in the intermediate shaft region. Based on sequence analysis, the β-bracelet motif of δ is conserved in all three nematode viruses and could account for ∼60% of the total length of the fiber. Our study indicated that δ plays important roles in cell attachment for this group of nematode viruses. In addition, the tightly knitted β-bracelet fold, which presumably allows δ to survive harsh environments in the worm gut, could be applicable to bioengineering applications given its potentially high stability.","journal":"Journal of Virology","year":2020,"id":83592,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":312738,"name":"Yanlin Fan","orcid":null,"position":1,"is_corresponding":false},{"id":430090,"name":"Ying Zhou","orcid":"0000-0001-8992-7897","position":2,"is_corresponding":false},{"id":430091,"name":"Miao Jin","orcid":"0000-0002-8442-5051","position":3,"is_corresponding":false},{"id":431182,"name":"Jim L. Zhang","orcid":null,"position":4,"is_corresponding":false},{"id":376207,"name":"Hongbing Jiang","orcid":"0000-0002-7320-3349","position":5,"is_corresponding":false},{"id":267542,"name":"Matthew V. Holt","orcid":"0000-0002-1418-6139","position":6,"is_corresponding":false},{"id":430092,"name":"Tao Wang","orcid":"0000-0002-9641-6558","position":7,"is_corresponding":false},{"id":267564,"name":"Nicolas L. Young","orcid":"0000-0002-3323-2815","position":8,"is_corresponding":false},{"id":227345,"name":"David Wang","orcid":"0000-0002-0827-196X","position":9,"is_corresponding":false},{"id":431183,"name":"Weiwei Zhong","orcid":null,"position":10,"is_corresponding":false},{"id":310422,"name":"Yizhi Jane Tao","orcid":"0000-0002-0149-2241","position":11,"is_corresponding":false},{"id":430089,"name":"Yusong R. Guo","orcid":"0000-0002-8563-3397","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-18T21:54:32.422022Z","pmid":"32817218","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}