{"doi":"10.1128/jvi.01526-20","title":"Computationally Optimized Broadly Reactive H2 HA Influenza Vaccines Elicited Broadly Cross-Reactive Antibodies and Protected Mice from Viral Challenges","abstract":"H2N2 influenza has caused at least one pandemic in the past. Given that individuals born after 1968 have not been exposed to H2N2 influenza viruses, a future pandemic caused by H2 influenza is likely. An effective H2 influenza vaccine would need to elicit broadly cross-reactive antibodies to multiple H2 influenza viruses. Choosing a wild-type virus to create a vaccine may elicit a narrow immune response and not protect against multiple H2 influenza viruses. COBRA H2 HA vaccines were developed and evaluated in mice along with wild-type H2 HA vaccines. Multiple COBRA H2 HA vaccines protected mice from all three viral challenges and produced broadly cross-reactive neutralizing antibodies to H2 influenza viruses.","journal":"Journal of Virology","year":2020,"id":64053,"datarank":0.8162030343314923,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"self_citation_contribution":0.5533319181170905,"citation_network_contribution":0.2628711162144019,"self_endowment_contribution":0.5533319181170905,"citer_contribution":0.2628711162144019,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":19,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9474,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":338991,"name":"Parker J. Jamieson","orcid":"0000-0001-8992-6747","position":1,"is_corresponding":false},{"id":299100,"name":"Amanda L. Skarlupka","orcid":"0000-0002-3654-9076","position":2,"is_corresponding":false},{"id":338992,"name":"Ying Huang","orcid":"0000-0002-6889-5301","position":3,"is_corresponding":false},{"id":245069,"name":"Ted M. Ross","orcid":"0000-0003-1947-7469","position":4,"is_corresponding":false},{"id":245059,"name":"Z. Beau Reneer","orcid":"0000-0002-5685-000X","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:12:32.635050Z","pmid":"33115871","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}