{"doi":"10.1128/jvi.01506-20","title":"Human Cytomegalovirus Interactions with the Basement Membrane Protein Nidogen 1","abstract":"We have found that HCMV infection promotes the elimination of the developmentally important basement membrane protein nidogen 1 (NID1) from its host. The virus both decreased transcription and induced degradation of expressed protein. Endothelial cell (EC) secretion of basement membrane proteins is critical for vascular wall integrity, and infection equivalently affected NID1 protein levels in these cells. We found that the absence of NID1 in an EC monolayer allowed increased transmigration of monocytes equivalent to that observed after infection of ECs. The importance of NID1 in development has been well documented. We found that NID1 protein was dramatically reduced in infected inner ear clinical samples. We believe that HCMV's attack on host NID1 favors viral dissemination at the cost of negative developmental ramifications in the infected fetus.","journal":"Journal of Virology","year":2020,"id":81563,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":421829,"name":"Hannah K. Jaeger","orcid":"0000-0003-3285-2139","position":1,"is_corresponding":false},{"id":421830,"name":"Onesmo B. Balemba","orcid":"0000-0003-1034-2242","position":2,"is_corresponding":false},{"id":423016,"name":"John M. O’Dowd","orcid":null,"position":3,"is_corresponding":false},{"id":421831,"name":"Deborah Duricka","orcid":"0000-0002-5057-6361","position":4,"is_corresponding":false},{"id":421832,"name":"Holger Hannemann","orcid":"0000-0001-8234-0209","position":5,"is_corresponding":false},{"id":423017,"name":"Emmerentia Marx","orcid":null,"position":6,"is_corresponding":false},{"id":421833,"name":"N. Teissier","orcid":"0000-0003-1050-1346","position":7,"is_corresponding":false},{"id":421834,"name":"Liliana Gabrielli","orcid":"0000-0002-5994-4749","position":8,"is_corresponding":false},{"id":421835,"name":"Maria Paola Bonasoni","orcid":"0000-0002-4889-1944","position":9,"is_corresponding":false},{"id":421836,"name":"Elizabeth M. Keithley","orcid":"0000-0001-7710-5052","position":10,"is_corresponding":false},{"id":421837,"name":"Elizabeth A. Fortunato","orcid":"0000-0003-2212-3645","position":11,"is_corresponding":false},{"id":423015,"name":"Man I Kuan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-18T21:52:58.921847Z","pmid":"33177203","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}