{"doi":"10.1128/jvi.01472-22","title":"Influence of Sex on Respiratory Syncytial Virus Genotype Infection Frequency and Nasopharyngeal Microbiome","abstract":"Respiratory syncytial virus (RSV) is one of the leading causes of lower respiratory tract infections in young children and is responsible for high hospitalization rates and morbidity in infants and the elderly. To understand how the emergence of RSV viral genotypes and viral-respiratory microbiome interactions contribute to infection frequency and severity, we utilized an observational cohort designed to capture the first infant RSV infection we employed multi-omics approaches to sequence 349 RSV complete genomes and matched nasopharyngeal microbiomes. We found non-G-72nt-duplicated RSV-A genotypes were more frequent in male infants, whereas G-72nt-duplicated RSV-A strains (ON1 lineage) were seen equally in both males and females. Microbiome analysis show Haemophilus was significantly more abundant in infants with RSV-A compared to infants with RSV-B infection and the microbial clustering of the abundant genera was associated with infant sex. Overall, we show sex differences in RSV genotype-nasopharyngeal microbiome, suggesting an interaction host genetics-virus-microbiome interaction.","journal":"Journal of Virology","year":2023,"id":359074,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8985,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":389434,"name":"Meghan H. Shilts","orcid":null,"position":1,"is_corresponding":false},{"id":388231,"name":"Christian Rosas‐Salazar","orcid":"0000-0001-6644-5780","position":2,"is_corresponding":false},{"id":1109727,"name":"Vinita Puri","orcid":"0000-0002-4214-8914","position":3,"is_corresponding":false},{"id":1109728,"name":"Nadia Fedorova","orcid":"0000-0002-5324-256X","position":4,"is_corresponding":false},{"id":270037,"name":"Rebecca Halpin","orcid":"0000-0002-2267-2145","position":5,"is_corresponding":false},{"id":614244,"name":"Siyuan Ma","orcid":"0000-0003-2313-6448","position":6,"is_corresponding":false},{"id":232941,"name":"Larry J. Anderson","orcid":"0000-0002-0652-6834","position":7,"is_corresponding":false},{"id":290007,"name":"R. Stokes Peebles","orcid":"0000-0002-1429-7875","position":8,"is_corresponding":false},{"id":275878,"name":"Tina V. Hartert","orcid":"0000-0001-7470-1166","position":9,"is_corresponding":false},{"id":270036,"name":"Suman R. Das","orcid":"0000-0003-2496-9724","position":10,"is_corresponding":false},{"id":267680,"name":"Yi Tan","orcid":"0000-0002-0542-5740","position":0,"is_corresponding":true}],"reference_count":80,"raw_metadata":null,"created_at":"2026-07-19T01:13:52.889556Z","pmid":"36815771","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}