{"doi":"10.1128/jvi.01370-15","title":"Adeno-Associated Virus Type 2 Rep68 Can Bind to Consensus Rep-Binding Sites on the Herpes Simplex Virus 1 Genome","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>Adeno-associated virus type 2 is known to inhibit replication of herpes simplex virus 1 (HSV-1). This activity has been linked to the helicase- and DNA-binding domains of the Rep68/Rep78 proteins. Here, we show that Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome and that the Rep helicase activity can inhibit replication of any DNA if binding is facilitated. Therefore, we hypothesize that inhibition of HSV-1 replication involves direct binding of Rep68/Rep78 to the HSV-1 genome.</jats:p>","journal":"Journal of Virology","year":2015,"id":671442,"datarank":0.30203982601725604,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.010153303658958978,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.010153303658958978,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1754130,"name":"Daniel L. Glauser","orcid":null,"position":1,"is_corresponding":false},{"id":1572561,"name":"Kurt Tobler","orcid":null,"position":2,"is_corresponding":false},{"id":1754131,"name":"Oleg Georgiev","orcid":null,"position":3,"is_corresponding":false},{"id":1754132,"name":"Rebecca Vogel","orcid":null,"position":4,"is_corresponding":false},{"id":1754133,"name":"Bernd Vogt","orcid":null,"position":5,"is_corresponding":false},{"id":1754134,"name":"Leticia Agúndez","orcid":null,"position":6,"is_corresponding":false},{"id":1631499,"name":"Michael Linden","orcid":null,"position":7,"is_corresponding":false},{"id":353641,"name":"Hildegard Büning","orcid":"0000-0002-3365-6933","position":8,"is_corresponding":false},{"id":1572563,"name":"Mathias Ackermann","orcid":null,"position":9,"is_corresponding":false},{"id":1754135,"name":"Cornel Fraefel","orcid":null,"position":10,"is_corresponding":false},{"id":1754129,"name":"Michael Seyffert","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Adeno-Associated Virus Type 2 Rep68 Can Bind to Consensus Rep-Binding Sites on the Herpes Simplex Virus 1 Genome","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>Adeno-associated virus type 2 is known to inhibit replication of herpes simplex virus 1 (HSV-1). This activity has been linked to the helicase- and DNA-binding domains of the Rep68/Rep78 proteins. Here, we show that Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome and that the Rep helicase activity can inhibit replication of any DNA if binding is facilitated. Therefore, we hypothesize that inhibition of HSV-1 replication involves direct binding of Rep68/Rep78 to the HSV-1 genome.</jats:p>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26292324","pmcid":"PMC4621131","openalex_id":"https://openalex.org/W2271372738","authors":[],"funders":[{"funder_name":"Swiss National Science Foundation","grant_id":"144094","title":"Molecular mechanisms of interaction between herpes simplex virus type 1 and adeno-associated virus type 2 in co-infected cells"}],"total_grants":1,"fwci":0.4099,"citation_percentile":0.67296966,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"bronze","license":"ASM Journals Non-Commercial TDM","oa_locations":[{"url":"https://jvi.asm.org/content/jvi/89/21/11150.full.pdf","host_type":"journal"},{"url":"https://jvi.asm.org/content/jvi/89/21/11150.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JVI.01370-15","host_type":"publisher"},{"url":"https://doi.org/10.1128/jvi.01370-15","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26292324","host_type":"repository"},{"url":"https://kups.ub.uni-koeln.de/38845/","host_type":"repository"},{"url":"https://www.zora.uzh.ch/id/eprint/113456/1/PU525a.pdf","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4621131","host_type":"repository"},{"url":"https://kclpure.kcl.ac.uk/portal/en/publications/ad177265-207c-4423-9017-f380c1d3a3fc","host_type":"repository"},{"url":"https://doi.org/10.5167/uzh-113456","host_type":"repository"},{"url":"https://dx.doi.org/10.5167/uzh-113456","host_type":""},{"url":"https://dx.doi.org/10.1128/jvi.01370-15","host_type":""},{"url":"https://sonar.ch/global/documents/35921","host_type":""},{"url":"https://www.zora.uzh.ch/id/eprint/113456/","host_type":""},{"url":"http://www.ncbi.nlm.nih.gov/pubmed/26292324","host_type":""}],"fields_of_study":["Herpesvirus Infections and Treatments","DNA Repair Mechanisms","Cytomegalovirus and herpesvirus research","0301 basic medicine","0303 health sciences","03 medical and health sciences","Binding Sites","Blotting, Western","DNA Helicases","DNA-Binding Proteins","Dependovirus","Genome, Viral","Herpesvirus 1, Human","Humans","Viral Proteins"],"mesh_terms":["Dependovirus","Binding Sites","DNA Helicases","DNA-Binding Proteins","Humans","Viral Proteins","Blotting, Western","Genome, Viral","Herpesvirus 1, Human"],"keywords":["Herpes simplex virus","Biology","Single-stranded binding protein","Genome","Helicase","DNA-binding protein","DNA replication","DNA","Viral replication","Virology","Molecular biology","Virus","Genetics","Gene","RNA","Transcription factor","2403 Immunology","1109 Insect Science","Binding Sites","2404 Microbiology","Blotting, Western","DNA Helicases","Genome, Viral","Herpesvirus 1, Human","Dependovirus","DNA-Binding Proteins","Viral Proteins","2406 Virology","Humans","570 Life sciences; biology","10244 Institute of Virology"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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