{"doi":"10.1128/jvi.01246-22","title":"Cellular Heterogeneity and Molecular Reprogramming of the Host Response during Influenza Acute Lung Injury","abstract":"A dysregulated host response develops acute lung injury during IAV infection. However, the pathological immune mechanism(s) associated with acute lung injury during IAV infection is yet to be elucidated. In this study, we performed scRNAseq to examine the dynamics of host responses during the peak of IAV-mediated lung injury. At the cellular level, our data reveal significant myelopoiesis predominated by monocytes and macrophages and the simultaneous disruption of the nonhematopoietic cell framework, crucial for regulating inflammation and barrier integrity in IAV-infected lungs. Molecularly, we observed a complex cellular network involving cell-cell communications and a number of unique regulons dictating the outcome of interferon and chemokine responses during peak lung injury. Our data present a unique atlas of cellular changes and the regulation of global and cell-specific host responses during IAV infection. We expect that this information will open new avenues to identify targets for therapeutic intervention against IAV lung injury.","journal":"Journal of Virology","year":2022,"id":292691,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":710500,"name":"Dan Justin Kalenda Yombo","orcid":"0000-0002-1469-503X","position":1,"is_corresponding":false},{"id":465946,"name":"Taylor Schmit","orcid":"0000-0002-7637-1110","position":2,"is_corresponding":false},{"id":282912,"name":"Zhihan Wang","orcid":"0000-0002-3617-477X","position":3,"is_corresponding":false},{"id":976767,"name":"Zahrasadat Navaeiseddighi","orcid":"0000-0002-4300-9748","position":4,"is_corresponding":false},{"id":829055,"name":"Venkatachelem Sathish","orcid":null,"position":5,"is_corresponding":false},{"id":322588,"name":"Ramkumar Mathur","orcid":"0000-0002-9317-2631","position":6,"is_corresponding":false},{"id":257445,"name":"Min Wu","orcid":"0000-0003-1205-982X","position":7,"is_corresponding":false},{"id":320770,"name":"Bony De Kumar","orcid":"0000-0001-8398-3775","position":8,"is_corresponding":false},{"id":350442,"name":"Junguk Hur","orcid":"0000-0002-0736-2149","position":9,"is_corresponding":false},{"id":718883,"name":"Nadeem Khan","orcid":"0000-0003-3511-6356","position":10,"is_corresponding":false},{"id":282916,"name":"Kai Guo","orcid":"0000-0002-4651-781X","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T00:30:46.209549Z","pmid":"36286482","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}