{"doi":"10.1128/jvi.01102-20","title":"Regional Brain Recovery from Acute Synaptic Injury in Simian Immunodeficiency Virus-Infected Rhesus Macaques Associates with Heme Oxygenase Isoform Expression","abstract":"Brain injury induced by acute simian (or human) immunodeficiency virus infection may persist or spontaneously resolve in different brain regions. Identifying the host factor(s) that promotes spontaneous recovery from such injury may reveal targets for therapeutic drug strategies for promoting recovery from acute neuronal injury. The gradual recovery from such injury observed in many, but not all, brain regions in the rhesus macaque model is consistent with the possible existence of a therapeutic window of opportunity for intervening to promote recovery, even in those regions not showing spontaneous recovery. In persons living with human immunodeficiency virus infection, such neuroprotective treatments could ultimately be considered as adjuncts to the initiation of antiretroviral drug therapy.","journal":"Journal of Virology","year":2020,"id":87592,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9486,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":445288,"name":"Rolando Garza","orcid":"0000-0003-2764-7800","position":1,"is_corresponding":false},{"id":446326,"name":"Maria E. Diaz Ortiz","orcid":null,"position":2,"is_corresponding":false},{"id":446327,"name":"Analise L. Gruenewald","orcid":null,"position":3,"is_corresponding":false},{"id":445289,"name":"Brandon L. Bastien","orcid":"0000-0002-6029-5846","position":4,"is_corresponding":false},{"id":283211,"name":"Rebecca Lobrovich","orcid":null,"position":5,"is_corresponding":false},{"id":227417,"name":"David J. Irwin","orcid":"0000-0002-5599-5098","position":6,"is_corresponding":false},{"id":105481,"name":"Michael R. Betts","orcid":"0000-0002-7690-1484","position":7,"is_corresponding":false},{"id":233497,"name":"Guido Silvestri","orcid":"0000-0001-6602-2470","position":8,"is_corresponding":false},{"id":445290,"name":"Dennis L. Kolson","orcid":"0000-0002-7596-5726","position":9,"is_corresponding":false},{"id":445287,"name":"Yoelvis García‐Mesa","orcid":"0000-0001-9674-1417","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-18T22:00:29.831859Z","pmid":"32669339","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}