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Our results extend and improve current knowledge on the mechanisms of IAV transcription and replication.</jats:p>","journal":"Journal of Virology","year":2018,"id":628056,"datarank":0.5244761342199721,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.0,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":69445,"name":"Xiaokun Liu","orcid":"0000-0002-7248-0758","position":1,"is_corresponding":false},{"id":1625899,"name":"Qingxia Gao","orcid":null,"position":2,"is_corresponding":false},{"id":1625900,"name":"Tailang Cheng","orcid":null,"position":3,"is_corresponding":false},{"id":770629,"name":"Rong Xiao","orcid":"0000-0002-1203-0261","position":4,"is_corresponding":false},{"id":1625902,"name":"Fan Ming","orcid":null,"position":5,"is_corresponding":false},{"id":1625904,"name":"Shishuo Zhang","orcid":null,"position":6,"is_corresponding":false},{"id":130551,"name":"Meilin Jin","orcid":"0000-0003-4332-4083","position":7,"is_corresponding":false},{"id":208377,"name":"Huanchun Chen","orcid":null,"position":8,"is_corresponding":false},{"id":913483,"name":"Wenjun Ma","orcid":"0000-0002-9266-4802","position":9,"is_corresponding":false},{"id":1625906,"name":"Hongbo Zhou","orcid":null,"position":10,"is_corresponding":false},{"id":1273844,"name":"Cha Yang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Nucleolar Protein LYAR Facilitates Ribonucleoprotein Assembly of Influenza A Virus","abstract":"<jats:p>Influenza A virus (IAV) must utilize the host cell machinery to replicate, but many of the mechanisms of IAV-host interaction remain poorly understood. Improved understanding of interactions between host factors and vRNP not only increases our basic knowledge of the molecular mechanisms of virus replication and pathogenicity but also provides insights into possible novel antiviral targets that are necessary due to the widespread emergence of drug-resistant IAV strains. Here, we have identified LYAR, a cell growth-regulating nucleolar protein, which interacts with viral RNP components and is important for efficient replication of IAVs and whose role in the IAV life cycle has never been reported. In addition, we further reveal the role of LYAR in viral RNA synthesis. Our results extend and improve current knowledge on the mechanisms of IAV transcription and replication.</jats:p>","is_dataset_classified":null,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30209172","pmcid":"PMC6232469","openalex_id":"https://openalex.org/W2892270459","authors":[],"funders":[{"funder_name":"Ministry of Agriculture of the People's Republic of China","grant_id":"2016YFD0500205","title":null},{"funder_name":"Ministry of Agriculture of the People's Republic of China","grant_id":"2016YFC1200201","title":null},{"funder_name":"Ministry of Agriculture of the People's Republic of China","grant_id":"31772752","title":null},{"funder_name":"Ministry of Agriculture of the People's Republic of China","grant_id":"31761133005","title":null},{"funder_name":"Ministry of Agriculture of the People's Republic of China","grant_id":"31572545","title":null},{"funder_name":"Ministry of Agriculture of the People's Republic of China","grant_id":"2016CFA056","title":null},{"funder_name":"Ministry of Agriculture of the People's Republic of China","grant_id":"2015ABA039","title":null},{"funder_name":"Kansas State University","grant_id":"OOE004","title":null}],"total_grants":8,"fwci":1.6518,"citation_percentile":0.83873985,"influential_citations":0,"citation_trend":[{"year":2019,"count":4},{"year":2020,"count":4},{"year":2021,"count":3},{"year":2022,"count":6},{"year":2023,"count":8},{"year":2024,"count":1},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://jvi.asm.org/content/jvi/92/23/e01042-18.full.pdf","host_type":"journal"},{"url":"https://jvi.asm.org/content/jvi/92/23/e01042-18.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JVI.01042-18","host_type":"publisher"},{"url":"https://doi.org/10.1128/jvi.01042-18","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30209172","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC6232469","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6232469","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6232469","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6232469?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Influenza Virus Research Studies","interferon and immune responses","RNA and protein synthesis mechanisms"],"mesh_terms":["DNA-Binding Proteins","Humans","Influenza, Human","Nuclear Proteins","Influenza A virus","Ribonucleoproteins","RNA, Viral","Virion","Virus Replication","RNA-Binding Proteins","RNA, Small Interfering","Host-Pathogen Interactions","HEK293 Cells"],"keywords":["Biology","Ribonucleoprotein","Virology","Influenza A virus","Virus","Orthomyxoviridae","H5N1 genetic structure","Viral matrix protein","Cell biology","Computational biology","Genetics","RNA","Gene","Coronavirus disease 2019 (COVID-19)","Host Factor","Vrnp","Lyar","Viral Rnp Assembly"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Responsible consumption and production"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T10:54:23.163323Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}