{"doi":"10.1128/jvi.00960-24","title":"Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics","abstract":"CD4-mimetics (CD4mcs) are small molecule compounds that mimic the interaction of the CD4 receptor with HIV-1 envelope glycoproteins (Env). Env from primary viruses normally samples a \"closed\" conformation that occludes epitopes recognized by CD4-induced (CD4i) non-neutralizing antibodies (nnAbs). CD4mcs induce conformational changes on Env resulting in the exposure of these otherwise inaccessible epitopes. Here, we evaluated the capacity of plasma from a cohort of 50 people living with HIV to recognize HIV-1-infected cells and eliminate them by antibody-dependent cellular cytotoxicity (ADCC) in the presence of a potent indoline CD4mc. We observed a marked heterogeneity among plasma samples. By measuring the levels of different families of CD4i Abs, we found that the levels of anti-cluster A, anti-coreceptor binding site, and anti-gp41 cluster I antibodies are responsible for plasma-mediated ADCC in the presence of CD4mc. IMPORTANCE: There are several reasons that make it difficult to target the HIV reservoir. One of them is the capacity of infected cells to prevent the recognition of HIV-1 envelope glycoproteins (Env) by commonly elicited antibodies in people living with HIV. Small CD4-mimetic compounds expose otherwise occluded Env epitopes, thus enabling their recognition by non-neutralizing antibodies (nnAbs). A better understanding of the contribution of these antibodies to eliminate infected cells in the presence of CD4mc could lead to the development of therapeutic cure strategies.","journal":"Journal of Virology","year":2024,"id":437207,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":807709,"name":"Lorie Marchitto","orcid":"0000-0002-4367-0229","position":1,"is_corresponding":false},{"id":1246656,"name":"Étienne Bélanger","orcid":null,"position":2,"is_corresponding":false},{"id":241571,"name":"Mehdi Benlarbi","orcid":"0000-0001-9966-3784","position":3,"is_corresponding":false},{"id":241565,"name":"Guillaume Beaudoin-Bussières","orcid":"0000-0002-8092-4101","position":4,"is_corresponding":false},{"id":241563,"name":"Jérémie Prévost","orcid":"0000-0002-5260-5154","position":5,"is_corresponding":false},{"id":908031,"name":"Derek Yang","orcid":"0000-0001-8959-384X","position":6,"is_corresponding":false},{"id":822652,"name":"Ta-Jung Chiu","orcid":"0000-0003-3816-8805","position":7,"is_corresponding":false},{"id":677237,"name":"Hung-Ching Chen","orcid":"0000-0002-3359-5878","position":8,"is_corresponding":false},{"id":621586,"name":"Catherine Bourassa","orcid":"0000-0003-1805-8860","position":9,"is_corresponding":false},{"id":243836,"name":"Halima Medjahed","orcid":null,"position":10,"is_corresponding":false},{"id":931789,"name":"Marek Korzeniowski","orcid":"0000-0002-5264-7303","position":11,"is_corresponding":false},{"id":546420,"name":"Suneetha Gottumukkala","orcid":null,"position":12,"is_corresponding":false},{"id":335146,"name":"William D. Tolbert","orcid":"0000-0001-7549-9596","position":13,"is_corresponding":false},{"id":241566,"name":"Jonathan Richard","orcid":"0000-0002-9015-9589","position":14,"is_corresponding":false},{"id":350337,"name":"Amos B. Smith","orcid":"0000-0002-1712-8567","position":15,"is_corresponding":false},{"id":335148,"name":"Marzena Pazgier","orcid":"0000-0003-0594-5057","position":16,"is_corresponding":false},{"id":241588,"name":"Andrés Finzi","orcid":"0000-0002-4992-5288","position":17,"is_corresponding":false},{"id":621585,"name":"Alexandra Tauzin","orcid":"0000-0001-9153-3600","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:00:29.872940Z","pmid":"39230306","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}