{"doi":"10.1128/jvi.00862-21","title":"SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway","abstract":"SARS-CoV-2 can infect various organs in the human body, but the molecular interface between the virus and these organs remains unexplored. In this study, we generated a panel of highly infectible human cell lines originating from various body organs and employed these cells to identify cellular processes commonly or distinctly disrupted by SARS-CoV-2 in different cell types. One among the universally impaired processes was interferon signaling. Systematic analysis of this pathway in diverse culture systems showed that SARS-CoV-2 targets the proximal JAK-STAT pathway components, destabilizes the type I interferon receptor though ubiquitination, and consequently renders the infected cells resistant to type I interferon. These findings illuminate how SARS-CoV-2 can continue to propagate in different tissues even in the presence of a disseminated innate immune response.","journal":"Journal of Virology","year":2021,"id":151178,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":85,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":642523,"name":"Nazimuddin Khan","orcid":"0000-0003-4811-9521","position":1,"is_corresponding":false},{"id":249891,"name":"Brianna J. Close","orcid":"0000-0002-0563-1464","position":2,"is_corresponding":false},{"id":266476,"name":"Raghuveera Kumar Goel","orcid":"0000-0001-7348-3996","position":3,"is_corresponding":false},{"id":253651,"name":"Benjamin C. Blum","orcid":"0000-0002-9525-7073","position":4,"is_corresponding":false},{"id":642524,"name":"Alexander H. Tavares","orcid":"0000-0002-8363-4505","position":5,"is_corresponding":false},{"id":471417,"name":"Devin Kenney","orcid":"0000-0002-8758-1930","position":6,"is_corresponding":false},{"id":249893,"name":"Hasahn L. Conway","orcid":"0000-0001-7328-3521","position":7,"is_corresponding":false},{"id":232948,"name":"Jourdan K. Ewoldt","orcid":"0000-0001-5466-8557","position":8,"is_corresponding":false},{"id":322671,"name":"Vipul C. Chitalia","orcid":"0000-0002-6663-6058","position":9,"is_corresponding":false},{"id":559047,"name":"Nicholas A. Crossland","orcid":"0000-0003-3873-9188","position":10,"is_corresponding":false},{"id":232957,"name":"Christopher S. Chen","orcid":"0000-0003-2445-8449","position":11,"is_corresponding":false},{"id":228731,"name":"Darrell N. Kotton","orcid":"0000-0002-9604-8476","position":12,"is_corresponding":false},{"id":77531,"name":"Susan C. Baker","orcid":"0000-0001-6485-8143","position":13,"is_corresponding":false},{"id":276936,"name":"Serge Y. Fuchs","orcid":"0000-0002-0136-5103","position":14,"is_corresponding":false},{"id":266494,"name":"John H. Connor","orcid":"0000-0002-8867-7256","position":15,"is_corresponding":false},{"id":642525,"name":"Florian Douam","orcid":"0000-0002-4791-6767","position":16,"is_corresponding":false},{"id":253656,"name":"Andrew Emili","orcid":"0000-0001-8995-246X","position":17,"is_corresponding":false},{"id":232300,"name":"Mohsan Saeed","orcid":"0000-0001-8505-7054","position":18,"is_corresponding":false},{"id":249892,"name":"Da‐Yuan Chen","orcid":"0000-0002-1957-3330","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-18T23:43:11.293086Z","pmid":"34260266","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}