{"doi":"10.1128/jvi.00758-23","title":"Liver X Receptor-Inducible Host E3 Ligase IDOL Targets a Human Cytomegalovirus Reactivation Determinant","abstract":"Herpesviruses establish lifelong latent infections, which pose an important risk for disease particularly in the immunocompromised. Our work is focused on the betaherpesvirus human cytomegalovirus (HCMV) that latently infects the majority of the population worldwide. Defining the mechanisms by which HCMV establishes latency or reactivates from latency is important for controlling viral disease. Here, we demonstrate that the cellular inducible degrader of low-density lipoprotein receptor (IDOL) targets a HCMV determinant of reactivation for degradation. The instability of this determinant is important for the establishment of latency. This work defines a pivotal virus-host interaction that allows HCMV to sense changes in host biology to navigate decisions to establish latency or to replicate.","journal":"Journal of Virology","year":2023,"id":371288,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":506641,"name":"Donna Collins-McMillen","orcid":"0000-0001-6593-1912","position":1,"is_corresponding":false},{"id":1011871,"name":"Sebastian Zeltzer","orcid":null,"position":2,"is_corresponding":false},{"id":554408,"name":"Jason Buehler","orcid":"0000-0002-0116-0044","position":3,"is_corresponding":false},{"id":500410,"name":"Melissa A. Moy","orcid":null,"position":4,"is_corresponding":false},{"id":1011427,"name":"Kristen Zarrella","orcid":"0000-0003-3142-6664","position":5,"is_corresponding":false},{"id":226711,"name":"Katie Caviness","orcid":"0000-0002-9175-7230","position":6,"is_corresponding":false},{"id":1011872,"name":"Louis Cicchini","orcid":null,"position":7,"is_corresponding":false},{"id":1011873,"name":"David J. Tafoya","orcid":null,"position":8,"is_corresponding":false},{"id":406503,"name":"Felicia Goodrum","orcid":"0000-0002-6646-7290","position":9,"is_corresponding":false},{"id":406501,"name":"Luwanika Mlera","orcid":"0000-0002-3261-3544","position":0,"is_corresponding":true}],"reference_count":114,"raw_metadata":null,"created_at":"2026-07-19T01:15:45.330525Z","pmid":"37338407","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}