{"doi":"10.1128/jvi.00728-22","title":"Pandemic 1918 Influenza Virus Does Not Cause Lethal Infection in Rhesus or Cynomolgus Macaques","abstract":"The world remains at risk of an influenza pandemic, and the development of new therapeutic and preventative modalities is critically important for minimizing human death and suffering during the next influenza pandemic. Animal models are central to the development of new therapies and vaccine approaches. In particular, nonhuman primates like rhesus and cynomolgus macaques are highly relevant preclinical models given their physiological and immunological similarities to humans. Unfortunately, there remains a scarcity of macaque models of pandemic influenza with which to test novel antiviral modalities. Here, we demonstrate that even at the highest doses tested, 1918 influenza was not lethal in these two macaque species, suggesting that they are not ideal for the development and testing of novel pandemic influenza-specific vaccines and therapies. Therefore, other physiologically relevant nonhuman primate models of pandemic influenza are needed.","journal":"Journal of Virology","year":2022,"id":285244,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9429,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":290903,"name":"Meenakshi Tiwary","orcid":"0000-0003-2468-8076","position":1,"is_corresponding":false},{"id":259643,"name":"Helen L. Wu","orcid":"0000-0001-7101-5160","position":2,"is_corresponding":false},{"id":719827,"name":"Nikesh Tailor","orcid":null,"position":3,"is_corresponding":false},{"id":719002,"name":"Robert Vendramelli","orcid":"0000-0002-9131-2602","position":4,"is_corresponding":false},{"id":839408,"name":"Jonathan Audet","orcid":"0000-0002-0743-7489","position":5,"is_corresponding":false},{"id":294446,"name":"Bryce M. Warner","orcid":"0000-0003-2635-5072","position":6,"is_corresponding":false},{"id":296574,"name":"Kevin Tierney","orcid":null,"position":7,"is_corresponding":false},{"id":963871,"name":"Alix Albietz","orcid":null,"position":8,"is_corresponding":false},{"id":963428,"name":"Thang Truong","orcid":"0000-0002-0707-7452","position":9,"is_corresponding":false},{"id":963872,"name":"Kaylie Doan","orcid":null,"position":10,"is_corresponding":false},{"id":963429,"name":"Alexander Bello","orcid":"0000-0003-2224-5829","position":11,"is_corresponding":false},{"id":963430,"name":"Marnie Willman","orcid":"0000-0001-6265-5457","position":12,"is_corresponding":false},{"id":719001,"name":"Bryan D. Griffin","orcid":"0000-0002-7950-1873","position":13,"is_corresponding":false},{"id":107190,"name":"Patrick W. Hanley","orcid":"0000-0003-2300-1818","position":14,"is_corresponding":false},{"id":107189,"name":"Jamie Lovaglio","orcid":"0000-0002-7567-446X","position":15,"is_corresponding":false},{"id":294451,"name":"David Safronetz","orcid":"0000-0002-9024-728X","position":16,"is_corresponding":false},{"id":963873,"name":"Jim Strong","orcid":null,"position":17,"is_corresponding":false},{"id":259654,"name":"Jonah B. Sacha","orcid":"0000-0002-7633-3122","position":18,"is_corresponding":false},{"id":719005,"name":"Darwyn Kobasa","orcid":"0000-0002-6371-7493","position":19,"is_corresponding":false},{"id":719828,"name":"Mable Chan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:29:40.826853Z","pmid":"35924920","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}