{"doi":"10.1128/jvi.00619-21","title":"Identification of Anti-Premembrane Antibody as a Serocomplex-Specific Marker To Discriminate Zika, Dengue, and West Nile Virus Infections","abstract":"Despite a decline in Zika virus (ZIKV) transmission since late 2017, questions regarding its surveillance, potential reemergence, and interactions with other flaviviruses in regions where it is endemic remain unanswered. Recent studies have reported reduced risks of symptomatic Zika by prior dengue virus (DENV) infection and increased risks of severe dengue disease by previous ZIKV or DENV infection, highlighting a need for better serological tests to discriminate past ZIKV, DENV, and/or other flavivirus infections and improved understanding of the immune interactions and vaccine strategy for these viruses. As most serological tests for ZIKV focused on envelope and nonstructural protein 1, antibodies to other ZIKV proteins, including potentially specific antibodies, remain understudied. We employed Western blot analysis using antigens of 6 flaviviruses to study antibody responses following well-documented ZIKV, DENV, and West Nile virus infections and identified anti-premembrane antibody as a flavivirus serocomplex-specific marker to delineate current and past flavivirus infections in areas where flaviviruses are endemic.","journal":"Journal of Virology","year":2021,"id":201404,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9618,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":743812,"name":"Wen-Yang Tsai","orcid":"0000-0002-3407-8223","position":1,"is_corresponding":false},{"id":780195,"name":"Jih‐Jin Tsai","orcid":"0000-0003-2226-8916","position":2,"is_corresponding":false},{"id":246884,"name":"Mars Stone","orcid":"0000-0001-5619-2767","position":3,"is_corresponding":false},{"id":250064,"name":"Graham Simmons","orcid":"0000-0002-9615-7023","position":4,"is_corresponding":false},{"id":36841,"name":"Michael P. Busch","orcid":"0000-0002-1446-125X","position":5,"is_corresponding":false},{"id":257586,"name":"Marion C. Lanteri","orcid":"0000-0002-4213-5013","position":6,"is_corresponding":false},{"id":235417,"name":"Susan L. Stramer","orcid":"0000-0002-5865-6366","position":7,"is_corresponding":false},{"id":236673,"name":"Ángel Balmaseda","orcid":"0000-0003-1174-4235","position":8,"is_corresponding":false},{"id":236674,"name":"Eva Harris","orcid":"0000-0002-7238-4037","position":9,"is_corresponding":false},{"id":596133,"name":"Wei‐Kung Wang","orcid":"0000-0002-6670-4663","position":10,"is_corresponding":false},{"id":780916,"name":"Szu‐Chia Hsieh","orcid":null,"position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:50:56.394488Z","pmid":"34232731","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}