{"doi":"10.1128/jvi.00593-21","title":"Structure, Immunogenicity, and Conformation-Dependent Receptor Binding of the Postfusion Human Metapneumovirus F Protein","abstract":"Human metapneumovirus (hMPV) is an important cause of viral respiratory disease. In this paper, we report the X-ray crystal structure of the hMPV fusion (F) protein in the postfusion conformation from genotype B. We also assessed binding of the hMPV F protein to heparin and heparan sulfate, a previously reported receptor for the hMPV F protein. Furthermore, we determined the immunogenicity and protective efficacy of postfusion hMPV B2 F protein, which is the first study using a homogenous conformation of the protein. Antibodies generated in response to vaccination give a balanced Th1/Th2 response and target two previously discovered neutralizing epitopes.","journal":"Journal of Virology","year":2021,"id":168664,"datarank":1.1173695871680063,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.6022715064952343,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.6022715064952343,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":23,"citers_with_citation_signal":16,"citers_with_endowment":16,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9617,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":313958,"name":"Pradeep Chopra","orcid":"0000-0002-6003-4574","position":1,"is_corresponding":false},{"id":53124,"name":"Lin Liu","orcid":"0000-0002-0310-5946","position":2,"is_corresponding":false},{"id":518820,"name":"Tamás Nagy","orcid":"0000-0003-3828-0485","position":3,"is_corresponding":false},{"id":621421,"name":"Jackelyn Murray","orcid":"0000-0001-6838-3579","position":4,"is_corresponding":false},{"id":551887,"name":"Ralph A. Tripp","orcid":"0000-0002-2924-9956","position":5,"is_corresponding":false},{"id":53134,"name":"Geert‐Jan Boons","orcid":"0000-0003-3111-5954","position":6,"is_corresponding":false},{"id":296075,"name":"Jarrod J. Mousa","orcid":"0000-0003-4709-2478","position":7,"is_corresponding":false},{"id":355921,"name":"Jiachen Huang","orcid":"0000-0001-7624-7390","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:46:06.853307Z","pmid":"34160259","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}