{"doi":"10.1128/jvi.00525-20","title":"Seminal Plasma-Derived Extracellular-Vesicle Fractions from HIV-Infected Men Exhibit Unique MicroRNA Signatures and Induce a Proinflammatory Response in Cells Isolated from the Female Reproductive Tract","abstract":"Seminal plasma (SP), the major vehicle for HIV, can modulate HIV transmission risk through a variety of mechanisms. Extracellular vesicles (EVs) are extremely abundant in semen, and because they play a key role in intercellular communication pathways and immune regulation, they may impact the likelihood of HIV transmission. However, little is known about the properties and signaling effects of SP-derived EVs in the context of HIV transmission. Here, we conduct a phenotypic, transcriptomic, and functional characterization of SP and SP-derived EVs from uninfected and HIV-infected men. We find that both SP and its associated EVs elicit potent proinflammatory transcriptional responses in cells that line the genital tract. EVs from HIV-infected men exhibit a more diverse repertoire of miRNAs than EVs from uninfected men. Our findings suggest that EVs from the semen of HIV-infected men may significantly impact the likelihood of HIV transmission through multiple mechanisms.","journal":"Journal of Virology","year":2020,"id":69766,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":369377,"name":"Karen S. Jang","orcid":"0000-0002-0000-3848","position":1,"is_corresponding":false},{"id":246063,"name":"Ashley F. George","orcid":"0000-0002-1482-5244","position":2,"is_corresponding":false},{"id":369378,"name":"Mette Nyegaard","orcid":"0000-0003-4973-8543","position":3,"is_corresponding":false},{"id":246058,"name":"Jason Neidleman","orcid":"0000-0003-3525-8047","position":4,"is_corresponding":false},{"id":370428,"name":"Heather C. Inglis","orcid":null,"position":5,"is_corresponding":false},{"id":369379,"name":"Ali Danesh","orcid":"0000-0002-0383-1040","position":6,"is_corresponding":false},{"id":370429,"name":"Xutao Deng","orcid":null,"position":7,"is_corresponding":false},{"id":370430,"name":"Amirali Afshari","orcid":null,"position":8,"is_corresponding":false},{"id":369380,"name":"Young Ho Kim","orcid":"0000-0003-0703-1136","position":9,"is_corresponding":false},{"id":369381,"name":"Jean-Noël Billaud","orcid":"0000-0002-8924-9069","position":10,"is_corresponding":false},{"id":369382,"name":"Kara Marson","orcid":"0000-0001-9534-0371","position":11,"is_corresponding":false},{"id":293287,"name":"Christopher D. Pilcher","orcid":null,"position":12,"is_corresponding":false},{"id":24132,"name":"Satish K. Pillai","orcid":"0000-0001-8770-7014","position":13,"is_corresponding":false},{"id":284370,"name":"Philip J. Norris","orcid":"0000-0003-0526-2088","position":14,"is_corresponding":false},{"id":71692,"name":"Nadia R. Roan","orcid":"0000-0002-5464-1976","position":15,"is_corresponding":false},{"id":369376,"name":"Erika G. Marques de Menezes","orcid":"0000-0002-3273-6755","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:42:48.813846Z","pmid":"32434889","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}