{"doi":"10.1128/jvi.00364-22","title":"Effective Interferon Lambda Treatment Regimen To Control Lethal MERS-CoV Infection in Mice","abstract":"Effective antiviral agents are urgently required to prevent and treat individuals infected with SARS-CoV-2 and other emerging viral infections. The COVID-19 pandemic has catapulted our efforts to identify, develop, and evaluate several antiviral agents. However, a narrow therapeutic window has limited the protective efficacy of several broad-spectrum and CoV-specific antivirals. IFN-λ is an antiviral agent of interest due to its ability to induce a robust endogenous antiviral state and low levels of inflammation. Here, we evaluated the protective efficacy and effective treatment regimen of IFN-λ in mice infected with a lethal dose of MERS-CoV. We show that while prophylactic and early therapeutic IFN-λ administration is protective, delayed treatment is detrimental. Notably, a combination of prophylactic and delayed therapeutic administration of IFN-λ protected mice from severe MERS. Our results highlight the prophylactic and therapeutic use of IFN-λ against lethal hCoV and likely other viral lung infections.","journal":"Journal of Virology","year":2022,"id":263149,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9471,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":553824,"name":"Abhishek Kumar Verma","orcid":"0000-0002-6816-2378","position":1,"is_corresponding":false},{"id":858639,"name":"Muneeswaran Selvaraj","orcid":"0000-0002-5335-529X","position":2,"is_corresponding":false},{"id":919562,"name":"Roshan Ghimire","orcid":"0000-0002-1397-3966","position":3,"is_corresponding":false},{"id":919563,"name":"Hans Henrik Gad","orcid":"0000-0001-8449-1115","position":4,"is_corresponding":false},{"id":245458,"name":"Rune Hartmann","orcid":"0000-0003-1159-066X","position":5,"is_corresponding":false},{"id":918330,"name":"Sunil More","orcid":"0000-0001-5007-8795","position":6,"is_corresponding":false},{"id":77538,"name":"Stanley Perlman","orcid":"0000-0003-4213-2354","position":7,"is_corresponding":false},{"id":241088,"name":"Volker Thiel","orcid":"0000-0002-5783-0887","position":8,"is_corresponding":false},{"id":244495,"name":"Rudragouda Channappanavar","orcid":"0000-0002-7608-1922","position":9,"is_corresponding":false},{"id":241078,"name":"Ronald Dijkman","orcid":"0000-0003-0320-2743","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:26:29.321923Z","pmid":"35588276","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}