{"doi":"10.1128/jvi.00330-21","title":"Recombinant Herpesvirus Vectors: Durable Immune Responses and Durable Protection against Simian Immunodeficiency Virus SIVmac239 Acquisition","abstract":"We report on the long-term follow-up of a group of rhesus macaques (RMs) that received an AIDS vaccine regimen and were subsequently protected against rectal acquisition of simian immunodeficiency virus (SIV) infection. The vaccination regimen employed included a live recombinant herpesvirus vector that establishes persistent infection in RMs. Consistent with the recurrent SIV antigen expression afforded by this herpesvirus vector, vaccinees maintained detectable SIV-specific immune responses for more than 1.5 years after the last vaccination. Importantly, these vaccinated RMs were significantly protected against a second round of rectal SIV exposures performed 1 year after the first SIV challenge phase. These results are relevant for HIV vaccine development because they show the potential of herpesvirus-based vectors to maintain functional antiretroviral immunity without the need for repeated boosting.","journal":"Journal of Virology","year":2021,"id":204915,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":432420,"name":"Michael J. Ricciardi","orcid":"0000-0002-8098-8666","position":1,"is_corresponding":false},{"id":432419,"name":"Lucas Gonzalez-Nieto","orcid":"0000-0003-1580-3044","position":2,"is_corresponding":false},{"id":286693,"name":"Eva G. Rakasz","orcid":"0000-0001-8197-5309","position":3,"is_corresponding":false},{"id":233484,"name":"Jeffrey D. Lifson","orcid":"0000-0002-9494-0268","position":4,"is_corresponding":false},{"id":352949,"name":"Ronald C. Desrosiers","orcid":"0000-0001-6851-3003","position":5,"is_corresponding":false},{"id":279513,"name":"David I. Watkins","orcid":"0000-0001-6582-3305","position":6,"is_corresponding":false},{"id":432418,"name":"Maurício A. Martins","orcid":"0000-0001-8336-216X","position":7,"is_corresponding":false},{"id":788314,"name":"Isabelle M. Castro","orcid":null,"position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-18T23:51:30.197308Z","pmid":"33910957","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}