{"doi":"10.1128/jvi.00286-23","title":"Identification and Analysis of Monoclonal Antibodies with Neutralizing Activity against Diverse SARS-CoV-2 Variants","abstract":"Omicron variants of SARS-CoV-2 acquired escape ability from host immunity and authorized antibody therapeutics and thereby have been spreading worldwide. We reported that patients infected with an early SARS-CoV-2 variant, D614G, and who received subsequent two-dose mRNA vaccination have high neutralizing antibody titer against Omicron lineages. It was speculated that the patients have neutralizing antibodies broadly effective against SARS-CoV-2 variants by targeting common epitopes. Here, we explored human monoclonal antibodies from B cells of the patients. One of the monoclonal antibodies, named MO1, showed high potency against broad SARS-CoV-2 variants including BA.2.75 and BA.5 variants. The results prove that monoclonal antibodies that have common neutralizing epitopes among several Omicrons were produced in patients infected with D614G and who received mRNA vaccination.","journal":"Journal of Virology","year":2023,"id":360644,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":456205,"name":"Mitsuhiro Nishimura","orcid":"0000-0001-9541-3614","position":1,"is_corresponding":false},{"id":576147,"name":"Lidya Handayani Tjan","orcid":"0000-0002-4349-5547","position":2,"is_corresponding":false},{"id":1112904,"name":"Silvia Sutandhio","orcid":null,"position":3,"is_corresponding":false},{"id":1112441,"name":"Maria Istiqomah Marini","orcid":"0000-0002-6238-4869","position":4,"is_corresponding":false},{"id":1112905,"name":"Gema Barlian Effendi","orcid":null,"position":5,"is_corresponding":false},{"id":569843,"name":"Hideki Shigematsu","orcid":"0000-0003-3951-8651","position":6,"is_corresponding":false},{"id":1112442,"name":"Koji Kato","orcid":"0000-0001-9846-5903","position":7,"is_corresponding":false},{"id":1112906,"name":"Natsumi Hasegawa","orcid":null,"position":8,"is_corresponding":false},{"id":1112907,"name":"Kaito Aoki","orcid":null,"position":9,"is_corresponding":false},{"id":1112443,"name":"Yukiya Kurahashi","orcid":"0000-0002-0707-3486","position":10,"is_corresponding":false},{"id":1112444,"name":"Koichi Furukawa","orcid":"0000-0002-3321-9784","position":11,"is_corresponding":false},{"id":1112908,"name":"Mai Shinohara","orcid":null,"position":12,"is_corresponding":false},{"id":1112445,"name":"Tomoka Nakamura","orcid":"0000-0002-0464-6269","position":13,"is_corresponding":false},{"id":1112446,"name":"Jun Arii","orcid":"0000-0002-1689-4016","position":14,"is_corresponding":false},{"id":1112447,"name":"Tatsuya Nagano","orcid":"0000-0003-0790-5139","position":15,"is_corresponding":false},{"id":1112909,"name":"Sachiko Nakamura","orcid":null,"position":16,"is_corresponding":false},{"id":1112448,"name":"Shigeru Sano","orcid":"0000-0002-8186-151X","position":17,"is_corresponding":false},{"id":1112449,"name":"Sachiyo Iwata","orcid":"0000-0001-7461-672X","position":18,"is_corresponding":false},{"id":1112450,"name":"Shinya Okamura","orcid":"0000-0002-3969-2855","position":19,"is_corresponding":false},{"id":576148,"name":"Yasuko Mori","orcid":"0000-0002-6595-8522","position":20,"is_corresponding":false},{"id":1112440,"name":"Hanako Ishimaru","orcid":"0009-0009-4977-9821","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T01:14:06.433417Z","pmid":"37191569","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}