{"doi":"10.1128/jvi.00271-21","title":"Link between Interleukin-23 and Anti-CD4 Autoantibody Production in Antiretroviral-Treated HIV-Infected Individuals","abstract":"In our published studies, we determine that pathological anti-CD4 IgGs from immunologic non-responders on virally-suppressive ART (CD4 cell counts < 350 cells/μL) mediated CD4+ T cell death via antibody-mediated cytotoxicity (ADCC), which play a role in poor CD4+ T cell recovery from ART. Up to 25% of HIV-infected individuals are non-responders and demonstrate increased morbidity and mortality. However, the mechanism of anti-CD4 autoantibody production in treated HIV remains unknown. In this study, we report that IL-23 may be the key cytokine to promote anti-CD4 autoantibody production after immunization in ART-treated HIV-infected individuals.","journal":"Journal of Virology","year":2021,"id":205817,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":789623,"name":"Min Li","orcid":"0000-0003-1968-9621","position":1,"is_corresponding":false},{"id":790280,"name":"Fuli Mi","orcid":null,"position":2,"is_corresponding":false},{"id":789624,"name":"Zhefeng Meng","orcid":"0000-0001-9396-0673","position":3,"is_corresponding":false},{"id":789625,"name":"Guoqiang Du","orcid":"0000-0002-1133-2209","position":4,"is_corresponding":false},{"id":777255,"name":"Lisa Martin","orcid":"0000-0002-2240-911X","position":5,"is_corresponding":false},{"id":446145,"name":"Hui Liu","orcid":"0000-0002-7669-9386","position":6,"is_corresponding":false},{"id":467695,"name":"Ping Jin","orcid":"0000-0002-3479-7607","position":7,"is_corresponding":false},{"id":790281,"name":"David Stroncek","orcid":null,"position":8,"is_corresponding":false},{"id":385134,"name":"Sonya L. Heath","orcid":"0000-0002-3826-0954","position":9,"is_corresponding":false},{"id":789626,"name":"Wei Jiang","orcid":"0000-0003-2769-2812","position":10,"is_corresponding":false},{"id":365575,"name":"Zhenwu Luo","orcid":null,"position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-18T23:51:37.630221Z","pmid":"33731459","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}