{"doi":"10.1128/jvi.00256-15","title":"Simian Immunodeficiency Virus SIVsab Infection of Rhesus Macaques as a Model of Complete Immunological Suppression with Persistent Reservoirs of Replication-Competent Virus: Implications for Cure Research","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            Simian immunodeficiency virus SIVsab infection is completely controlled in rhesus macaques (RMs) through functional immune responses. We report that in SIVsab-infected RMs, (i) viral replication is controlled to &lt;0 to 3 copies/ml, (ii) about one-third of the virus strains in reservoirs are replication incompetent, and (iii) rebounding virus after CD8\n            <jats:sup>+</jats:sup>\n            cell depletion is replication competent and genetically similar to the original virus stock, suggesting early reservoir seeding. This model permits assessment of strategies aimed at depleting the reservoir without multidrug antiretroviral therapy.\n          </jats:p>","journal":"Journal of Virology","year":2015,"id":605772,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":461831,"name":"Cuiling Xu","orcid":"0000-0002-2269-7772","position":1,"is_corresponding":false},{"id":109265,"name":"Anthony R. Cillo","orcid":"0000-0002-3213-3129","position":2,"is_corresponding":false},{"id":1554792,"name":"Benjamin Policicchio","orcid":null,"position":3,"is_corresponding":false},{"id":1554793,"name":"Jan Kristoff","orcid":null,"position":4,"is_corresponding":false},{"id":1554794,"name":"George Haret-Richter","orcid":null,"position":5,"is_corresponding":false},{"id":258969,"name":"John W. Mellors","orcid":"0000-0002-3737-9742","position":6,"is_corresponding":false},{"id":295815,"name":"Ivona Pandrea","orcid":"0000-0002-4041-2961","position":7,"is_corresponding":false},{"id":407393,"name":"Cristian Apetrei","orcid":"0000-0002-0322-7185","position":8,"is_corresponding":false},{"id":408256,"name":"Dongzhu Ma","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Simian Immunodeficiency Virus SIVsab Infection of Rhesus Macaques as a Model of Complete Immunological Suppression with Persistent Reservoirs of Replication-Competent Virus: Implications for Cure Research","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            Simian immunodeficiency virus SIVsab infection is completely controlled in rhesus macaques (RMs) through functional immune responses. We report that in SIVsab-infected RMs, (i) viral replication is controlled to &lt;0 to 3 copies/ml, (ii) about one-third of the virus strains in reservoirs are replication incompetent, and (iii) rebounding virus after CD8\n            <jats:sup>+</jats:sup>\n            cell depletion is replication competent and genetically similar to the original virus stock, suggesting early reservoir seeding. This model permits assessment of strategies aimed at depleting the reservoir without multidrug antiretroviral therapy.\n          </jats:p>","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25833043","pmcid":"PMC4442440","openalex_id":"https://openalex.org/W2151742210","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"P01 AI088564","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"R01 RR025781","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"T32 AI065380","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL117715","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"T32AI065380-10","title":null},{"funder_name":"NIDCR NIH HHS","grant_id":"R56 DE023508","title":null}],"total_grants":6,"fwci":0.7821,"citation_percentile":0.70986359,"influential_citations":0,"citation_trend":[{"year":2016,"count":3},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":3}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://jvi.asm.org/content/jvi/89/11/6155.full.pdf","host_type":"journal"},{"url":"https://jvi.asm.org/content/jvi/89/11/6155.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JVI.00256-15","host_type":"publisher"},{"url":"https://doi.org/10.1128/jvi.00256-15","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25833043","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4442440","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","HIV/AIDS Research and Interventions","HIV/AIDS drug development and treatment"],"mesh_terms":["Animals","Immune Tolerance","Macaca mulatta","Male","Virus Replication","Simian Immunodeficiency Virus","Simian Acquired Immunodeficiency Syndrome","CD8-Positive T-Lymphocytes","Simian immunodeficiency virus"],"keywords":["Simian immunodeficiency virus","Biology","Virology","Virus","Viral replication","Immune system","Human immunodeficiency virus (HIV)","Replication (statistics)","Immunology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:12:32.445200Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}