{"doi":"10.1128/jvi.00176-21","title":"A Norovirus Uses Bile Salts To Escape Antibody Recognition While Enhancing Receptor Binding","abstract":"The major feature of calicivirus capsids is the 90 protruding domains (P domains) that are the site of cell receptor attachment and antibody epitopes. We demonstrated previously that these P domains are highly mobile and that bile causes these \"floating\" P domains in mouse norovirus (MNV) to contract onto the shell surface. Here, we present the near-atomic cryo-EM structure of the isolated MNV P domain complexed with a neutralizing Fab fragment. Our data show that bile causes two sets of changes. First, bile causes allosteric conformational changes in the epitopes at the top of the P domain that block antibody binding. Second, bile causes the P domain dimer subunits to rotate relative to each other, causing a contraction of the P domain that buries epitopes at the base of the P and shell domains. Taken together, the results show that MNV uses the host's own metabolites to enhance cell receptor binding while simultaneously blocking antibody recognition.","journal":"Journal of Virology","year":2021,"id":175287,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9619,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":318450,"name":"Michael B. Sherman","orcid":"0000-0002-3680-8066","position":1,"is_corresponding":false},{"id":484056,"name":"Hong Q. Smith","orcid":null,"position":2,"is_corresponding":false},{"id":715818,"name":"Stefan Taube","orcid":"0000-0002-9159-3651","position":3,"is_corresponding":false},{"id":405162,"name":"B. Montgomery Pettitt","orcid":"0000-0003-4902-3046","position":4,"is_corresponding":false},{"id":288650,"name":"Christiane E. Wobus","orcid":"0000-0001-5286-0924","position":5,"is_corresponding":false},{"id":483339,"name":"Thomas J. Smith","orcid":"0000-0002-0978-1494","position":6,"is_corresponding":false},{"id":715817,"name":"Alexis Williams","orcid":"0000-0002-5283-5822","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-18T23:47:11.249697Z","pmid":"33827952","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}