{"doi":"10.1128/jvi.00165-20","title":"Defective Influenza A Virus RNA Products Mediate MAVS-Dependent Upregulation of Human Leukocyte Antigen Class I Proteins","abstract":"Human leukocyte antigens (HLAs) are cell surface proteins that regulate innate and adaptive immune responses to viral infection by engaging with receptors on immune cells. Many viruses have evolved ways to evade host immune responses by modulating HLA expression and/or processing. Here, we provide evidence that aberrant RNA products of influenza virus genome replication can trigger retinoic acid-inducible gene I (RIG-I)/mitochondrial antiviral signaling (MAVS)-dependent remodeling of the cell surface, increasing surface presentation of HLA proteins known to inhibit the activation of an immune cell known as a natural killer (NK) cell. While this HLA upregulation would seem to be advantageous to the virus, it is kept in check by the viral nonstructural 1 (NS1) protein, which limits RIG-I activation and interferon production by the infected cell.","journal":"Journal of Virology","year":2020,"id":77304,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":402621,"name":"Brendon Parsons","orcid":"0000-0002-9255-0290","position":1,"is_corresponding":false},{"id":402622,"name":"Emma L. Price","orcid":"0000-0003-4403-6614","position":2,"is_corresponding":false},{"id":403590,"name":"Patrick D. Slaine","orcid":null,"position":3,"is_corresponding":false},{"id":403591,"name":"Becca L. Chilvers","orcid":null,"position":4,"is_corresponding":false},{"id":403592,"name":"Gregory S. Seaton","orcid":null,"position":5,"is_corresponding":false},{"id":402623,"name":"Andrew Wight","orcid":"0000-0003-3116-8722","position":6,"is_corresponding":false},{"id":402624,"name":"Daniel Medina-Luna","orcid":"0000-0001-8268-0377","position":7,"is_corresponding":false},{"id":403593,"name":"Sayanti Dey","orcid":null,"position":8,"is_corresponding":false},{"id":402625,"name":"Shannen Grandy","orcid":"0000-0002-8441-8222","position":9,"is_corresponding":false},{"id":403594,"name":"Lauryn E. Anderson","orcid":null,"position":10,"is_corresponding":false},{"id":402626,"name":"Natalia Zamorano Cuervo","orcid":"0000-0001-9199-9654","position":11,"is_corresponding":false},{"id":402627,"name":"Nathalie Grandvaux","orcid":"0000-0003-0567-0284","position":12,"is_corresponding":false},{"id":402628,"name":"Marta Gaglia","orcid":"0000-0002-1791-0663","position":13,"is_corresponding":false},{"id":402629,"name":"Alyson A. Kelvin","orcid":"0000-0003-0940-0847","position":14,"is_corresponding":false},{"id":402630,"name":"Denys A. Khaperskyy","orcid":"0000-0003-0583-7179","position":15,"is_corresponding":false},{"id":402631,"name":"Craig McCormick","orcid":"0000-0003-2794-3722","position":16,"is_corresponding":false},{"id":402632,"name":"Andrew P. Makrigiannis","orcid":"0000-0002-7258-9411","position":17,"is_corresponding":false},{"id":402620,"name":"Mir Munir A. Rahim","orcid":"0000-0002-4622-1082","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-18T21:48:50.085103Z","pmid":"32321802","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}