{"doi":"10.1128/jvi.00089-20","title":"T Cell Responses Induced by Attenuated Flavivirus Vaccination Are Specific and Show Limited Cross-Reactivity with Other Flavivirus Species","abstract":"The envelope (E) protein is the dominant target of neutralizing antibodies for dengue virus (DENV) and yellow fever virus (YFV). Accordingly, several DENV vaccine constructs use the E protein in a live attenuated vaccine format, utilizing a backbone derived from a heterologous flavivirus (such as YF) as a delivery vector. This backbone comprises the nonstructural (NS) and capsid (C) antigens, which are dominant targets of T cell responses. Here, we demonstrate that cross-reactivity at the level of T cell responses among different flaviviruses is very limited, despite high levels of sequence homology. Thus, the use of heterologous flavivirus species as a live attenuated vaccine vector is not likely to generate optimal T cell responses and might thus impair vaccine performance.","journal":"Journal of Virology","year":2020,"id":64916,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":70,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9645,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":343641,"name":"Hannah Voic","orcid":null,"position":1,"is_corresponding":false},{"id":342838,"name":"Sandeep Kumar Dhanda","orcid":"0000-0003-1381-7434","position":2,"is_corresponding":false},{"id":342839,"name":"Conner K. Kidd","orcid":"0000-0002-0152-2877","position":3,"is_corresponding":false},{"id":282037,"name":"James D. Brien","orcid":"0000-0002-1670-8041","position":4,"is_corresponding":false},{"id":56543,"name":"Søren Buus","orcid":"0000-0001-8363-1999","position":5,"is_corresponding":false},{"id":342840,"name":"Anette Stryhn","orcid":"0000-0002-4581-3553","position":6,"is_corresponding":false},{"id":342841,"name":"Anna P. Durbin","orcid":"0000-0002-6652-2851","position":7,"is_corresponding":false},{"id":342842,"name":"Stephen S. Whitehead","orcid":"0000-0001-6707-482X","position":8,"is_corresponding":false},{"id":246856,"name":"Sean A. Diehl","orcid":"0000-0001-9700-235X","position":9,"is_corresponding":false},{"id":342843,"name":"Aruna Dharshan De Silva","orcid":"0000-0001-5291-9543","position":10,"is_corresponding":false},{"id":236673,"name":"Ángel Balmaseda","orcid":"0000-0003-1174-4235","position":11,"is_corresponding":false},{"id":236674,"name":"Eva Harris","orcid":"0000-0002-7238-4037","position":12,"is_corresponding":false},{"id":103766,"name":"Daniela Weiskopf","orcid":"0000-0003-2968-7371","position":13,"is_corresponding":false},{"id":55670,"name":"Alessandro Sette","orcid":"0000-0001-7013-2250","position":14,"is_corresponding":false},{"id":292649,"name":"Alba Grifoni","orcid":"0000-0002-2209-5966","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-18T21:12:58.081635Z","pmid":"32132233","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}