{"doi":"10.1128/jvi.00065-23","title":"The <i>alg-1</i> Gene Is Necessary for Orsay Virus Replication in Caenorhabditis elegans","abstract":"All viruses are obligate intracellular parasites that recruit the cellular machinery of the host they infect to support their own proliferation. We used Caenorhabditis elegans and its only known infecting virus, Orsay virus, to identify host proteins relevant for virus infection. We determined that ALG-1, a protein previously known to be important in influencing worm life span and the expression levels of thousands of genes, is required for Orsay virus infection of C. elegans. This is a new function attributed to ALG-1 that was not recognized before. In humans, it has been shown that AGO2, a close relative protein to ALG-1, is essential for hepatitis C virus replication. This demonstrates that through evolution from worms to humans, some proteins have maintained similar functions, and consequently, this suggests that studying virus infection in a simple worm model has the potential to provide novel insights into strategies used by viruses to proliferate.","journal":"Journal of Virology","year":2023,"id":357748,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":376208,"name":"Luis Enrique Sandoval Del Prado","orcid":"0000-0001-6613-0383","position":1,"is_corresponding":false},{"id":1107930,"name":"Sydney Goldacker","orcid":null,"position":2,"is_corresponding":false},{"id":894140,"name":"Chika Fujii","orcid":"0000-0002-7494-5424","position":3,"is_corresponding":false},{"id":649655,"name":"Amanda N. Pinski","orcid":"0000-0003-3969-5009","position":4,"is_corresponding":false},{"id":1107931,"name":"Jon Zielke","orcid":null,"position":5,"is_corresponding":false},{"id":227345,"name":"David Wang","orcid":"0000-0002-0827-196X","position":6,"is_corresponding":false},{"id":689140,"name":"Ciro Cubillas","orcid":"0000-0002-2238-8048","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T01:13:39.186262Z","pmid":"37017532","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}