{"doi":"10.1128/jvi.00053-19","title":"Ceramide Suppresses Influenza A Virus Replication\n            <i>In Vitro</i>","abstract":"<jats:p>\n            Understanding the effect of sphingolipid metabolism on viral pathogenesis provide important insights into the development of therapeutic strategies against microbial infections. In this study, we demonstrate a critical role of ceramide during influenza A virus infection. We demonstrate that ceramide produced through\n            <jats:italic>de novo</jats:italic>\n            biosynthesis possess an antiviral role. These observations unlock new opportunities for the development of novel antiviral therapies against influenza.\n          </jats:p>","journal":"Journal of Virology","year":2019,"id":598894,"datarank":0.5926865577872142,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":0.0,"self_endowment_contribution":0.5926865577872142,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1534868,"name":"Rouba Hage-Sleiman","orcid":null,"position":1,"is_corresponding":false},{"id":1534870,"name":"Walid Karam","orcid":null,"position":2,"is_corresponding":false},{"id":490852,"name":"Ghassan Dbaibo","orcid":"0000-0002-5813-5878","position":3,"is_corresponding":false},{"id":1245890,"name":"Hassan Zaraket","orcid":"0000-0003-3807-6409","position":4,"is_corresponding":false},{"id":1161212,"name":"Nadia Soudani","orcid":"0000-0002-0191-7860","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ceramide Suppresses Influenza A Virus Replication\n            <i>In Vitro</i>","abstract":"<jats:p>\n            Understanding the effect of sphingolipid metabolism on viral pathogenesis provide important insights into the development of therapeutic strategies against microbial infections. In this study, we demonstrate a critical role of ceramide during influenza A virus infection. We demonstrate that ceramide produced through\n            <jats:italic>de novo</jats:italic>\n            biosynthesis possess an antiviral role. These observations unlock new opportunities for the development of novel antiviral therapies against influenza.\n          </jats:p>","is_dataset_classified":null,"base_score":3.912023005428146,"endowment":3.912023005428146,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30700605","pmcid":"PMC6430560","openalex_id":"https://openalex.org/W2911957497","authors":[],"funders":[{"funder_name":"American University of Beirut","grant_id":"","title":null}],"total_grants":1,"fwci":2.1543,"citation_percentile":0.88040123,"influential_citations":0,"citation_trend":[{"year":2019,"count":2},{"year":2020,"count":7},{"year":2021,"count":13},{"year":2022,"count":4},{"year":2023,"count":6},{"year":2024,"count":7},{"year":2025,"count":5},{"year":2026,"count":5}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://jvi.asm.org/content/jvi/93/7/e00053-19.full.pdf","host_type":"journal"},{"url":"https://jvi.asm.org/content/jvi/93/7/e00053-19.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JVI.00053-19","host_type":"publisher"},{"url":"https://doi.org/10.1128/jvi.00053-19","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30700605","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6430560","host_type":"repository"}],"fields_of_study":["Sphingolipid Metabolism and Signaling","Lipid Membrane Structure and Behavior","Immune Cell Function and Interaction","A549 Cells","Animals","Antiviral Agents","Cell Line","Cell Line, Tumor","Ceramides","Dogs","Epithelial Cells","Humans","Influenza A Virus, H1N1 Subtype","Influenza, Human","Madin Darby Canine Kidney Cells","Orthomyxoviridae Infections","Virus Replication"],"mesh_terms":["A549 Cells","Animals","Antiviral Agents","Cell Line","Ceramides","Dogs","Epithelial Cells","Humans","Influenza, Human","Orthomyxoviridae Infections","Virus Replication","Cell Line, Tumor","Influenza A Virus, H1N1 Subtype","Madin Darby Canine Kidney Cells"],"keywords":["Ceramide","Biology","Viral replication","Sphingolipid","Influenza A virus","Ceramide synthase","Virus","Cell biology","Sphingosine","Lipid signaling","Virology","Immunology","Biochemistry","Inflammation","Apoptosis","Influenza Virus","Sphingolipids","Serine Palmitoyltransferase","De Novo Pathway","Ceramide Analogue"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T16:22:38.552492Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}