{"doi":"10.1128/jvi.00003-21","title":"Bone Marrow-Derived SH-SY5Y Neuroblastoma Cells Infected with Kaposi’s Sarcoma-Associated Herpesvirus Display Unique Infection Phenotypes and Growth Properties","abstract":"Our study has provided evidence that neuronal SH-SY5Y cells displayed unique cellular responses upon KSHV infection. Unlike other infected cells, this neuronal cell line displayed a higher growth rate upon infection and can spontaneously transition back and forth between latent and lytic phases of infection. Unlike other latently infected cells, a number of lytic genes were also expressed in the latent phase of infection in addition to the established latent viral genes. They may play a role in deregulating a number of host genes that are involved in cell signaling and tumorigenesis in order to sustain the infection and growth advantages for the cells. Our study has provided novel insights into KSHV infection of neuronal cells and a potential new model for further studies to explore the underlying mechanism in viral and host interactions for neuronal cells and the association of KSHV with neuronal diseases.","journal":"Journal of Virology","year":2021,"id":189059,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":751048,"name":"Dongmei Li","orcid":"0000-0002-3186-072X","position":1,"is_corresponding":false},{"id":751049,"name":"Amirsalar Mansouri","orcid":"0000-0001-9014-5024","position":2,"is_corresponding":false},{"id":751050,"name":"Guobin Kang","orcid":"0000-0002-5421-2047","position":3,"is_corresponding":false},{"id":751051,"name":"Khalid Sayood","orcid":"0000-0001-8010-5272","position":4,"is_corresponding":false},{"id":237655,"name":"John T. West","orcid":"0000-0003-4594-6855","position":5,"is_corresponding":false},{"id":237656,"name":"Charles Wood","orcid":"0000-0002-4256-1530","position":6,"is_corresponding":false},{"id":751047,"name":"Xiaohong Kong","orcid":"0000-0002-2543-9066","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-18T23:49:14.547082Z","pmid":"33853962","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}