{"doi":"10.1128/jcm.34.3.569-574.1996","title":"Hepatitis C virus (HCV) subtype prevalence in Chiang Mai, Thailand, and identification of novel subtypes of HCV major type 6","abstract":"<jats:p>Subtype analysis of hepatitis C viruses (HCVs) obtained from patients with chronic liver disease in Chiang Mai, Thailand, was performed. Of 46 HCV isolates, 13 (28%) were shown to belong to HCV subtype 3a (HCV-3a), 10 (22%) to belong to HCV-1a, 7 (15%) to belong to HCV-1b, 1 (2%) to belong to HCV-3b, and 1 (2%) to belong to a variant group, as determined from partial nucleotide sequences of the NS5B region of the viral genome. Analysis of 5' untranslated region sequences identified five other isolates (11%) of HCV type 1 and two other isolates (4%) of type 3. Detailed phylogenetic positions for the variant described above and those previously obtained from blood donors and drug addicts in Chiang Mai were determined by a six-parameter neighbor-joining method on the basis of core, E1, and NS5B region sequences. The results revealed that those sequence variants represent novel subtypes of HCV type 6. The HCV type 6 isolates appear to be antigenically different from isolates of HCV types 1 and 2, as determined by a serotyping method that utilizes recombinant peptides corresponding to a portion of the NS4 protein. The significance of subtype analysis around this area is discussed.</jats:p>","journal":"Journal of Clinical Microbiology","year":1996,"id":20545,"datarank":3.6081438641696484,"base_score":4.248495242049359,"endowment":4.248495242049359,"self_citation_contribution":0.637274286307404,"citation_network_contribution":2.9708695778622443,"self_endowment_contribution":0.637274286307404,"citer_contribution":2.9708695778622443,"corpus_percentile":null,"corpus_rank":null,"citation_count":69,"citer_count":37,"citers_with_citation_signal":34,"citers_with_endowment":34,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":135417,"name":"C Apichartpiyakul","orcid":null,"position":1,"is_corresponding":false},{"id":135418,"name":"K I Ohba","orcid":null,"position":2,"is_corresponding":false},{"id":135419,"name":"M Mizokami","orcid":null,"position":3,"is_corresponding":false},{"id":135420,"name":"H Hotta","orcid":null,"position":4,"is_corresponding":false},{"id":135416,"name":"H Doi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.248495242049359,"endowment":4.248495242049359,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8904416","pmcid":"PMC228848","openalex_id":"https://openalex.org/W2109871760","authors":[],"funders":[],"total_grants":0,"fwci":3.5964,"citation_percentile":0.93697014,"influential_citations":11,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":1},{"year":2014,"count":2},{"year":2017,"count":1},{"year":2019,"count":1},{"year":2021,"count":2},{"year":2023,"count":2}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://jcm.asm.org/content/jcm/34/3/569.full.pdf","host_type":"journal"},{"url":"https://jcm.asm.org/content/jcm/34/3/569.full.pdf","host_type":"BRONZE"},{"url":"https://jcm.asm.org/content/jcm/34/3/569.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/jcm.34.3.569-574.1996","host_type":"publisher"},{"url":"https://doi.org/10.1128/jcm.34.3.569-574.1996","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8904416","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC228848","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/228848","host_type":"repository"}],"fields_of_study":["Hepatitis C virus research","Monoclonal and Polyclonal Antibodies Research","Hepatitis B Virus Studies","Biology","Medicine","Adult","Base Sequence","Female","Hepacivirus","Humans","Male","Middle Aged","Molecular Sequence Data","Phylogeny","Prevalence","Serotyping"],"mesh_terms":["Adult","Base Sequence","Female","Humans","Male","Middle Aged","Molecular Sequence Data","Phylogeny","Serotyping","Prevalence","Hepacivirus"],"keywords":["NS5B","Virology","Hepatitis C virus","Flaviviridae","Biology","Serotype","Hepacivirus","Virus","Hepatitis C","Sequence analysis","Genetics","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-05T22:08:20.201128Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}