{"doi":"10.1128/jcm.01643-20","title":"Diagnostic Accuracy Study of a Novel Blood-Based Assay for Identification of Tuberculosis in People Living with HIV","abstract":"The areas under the concentration-time curve (AUCs) for Xpert-MTB-HR-Prototype were 0.89 (confidence interval [CI], 0.83 to 0.94) against the CMRS and 0.94 (CI, 0.89 to 0.98) against Xpert MTB/RIF. Considering Xpert-MTB-HR-Prototype as a triage test (at the nearest upper value of sensitivity to 90%), specificities were 55.8% (CI, 47.2 to 64.1%) compared to the CMRS and 85.9% (CI, 79.3 to 90.7%) compared to Xpert MTB/RIF as confirmatory tests. Considering Xpert-MTB-HR-Prototype as a stand-alone diagnostic test, at a specificity near 95%, the test achieved a sensitivity of 65.7% (CI, 53.7 to 75.9%), while the CRP assay achieved a sensitivity of only 13.6% (CI, 7.3 to 23.4%). In this first accuracy study of a prototype blood-based host marker assay, we show the possible value of the assay for triage and diagnosis in PLHIV.","journal":"Journal of Clinical Microbiology","year":2020,"id":66724,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":50,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":353493,"name":"Stefano Ongarello","orcid":"0000-0002-0032-0691","position":1,"is_corresponding":false},{"id":287960,"name":"Anna Mantsoki","orcid":"0000-0001-8434-916X","position":2,"is_corresponding":false},{"id":354778,"name":"Romain Wyss","orcid":null,"position":3,"is_corresponding":false},{"id":354779,"name":"David H. Persing","orcid":null,"position":4,"is_corresponding":false},{"id":354780,"name":"Sara Banderby","orcid":null,"position":5,"is_corresponding":false},{"id":354781,"name":"Linda Strömqvist Meuzelaar","orcid":null,"position":6,"is_corresponding":false},{"id":354782,"name":"Jacqueline Prieto","orcid":null,"position":7,"is_corresponding":false},{"id":353494,"name":"Devasena Gnanashanmugam","orcid":"0000-0002-4397-7028","position":8,"is_corresponding":false},{"id":4851,"name":"Purvesh Khatri","orcid":"0000-0002-4143-4708","position":9,"is_corresponding":false},{"id":287967,"name":"Samuel G. Schumacher","orcid":"0000-0002-6136-206X","position":10,"is_corresponding":false},{"id":287968,"name":"Claudia M. Denkinger","orcid":"0000-0002-7216-7067","position":11,"is_corresponding":false},{"id":353492,"name":"Erik Södersten","orcid":"0000-0002-2998-4889","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-18T21:14:50.590588Z","pmid":"33298607","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}