{"doi":"10.1128/jcm.00332-21","title":"Manual Reading of Sensititre Broth Microdilution System Panels Improves Accuracy of Susceptibility Reporting for Polymyxin Antibiotics","abstract":", Pseudomonas aeruginosa, and Acinetobacter baumannii complex clinical isolates. MICs derived from the Sensititre instrument based on two operator comparisons demonstrated overall categorical agreement (CA) of 86% and 89% compared to AD for colistin and 89% and 92% compared to AD for polymyxin B. However, error rates were higher than recommended by CLSI. Manual inspection of microdilution wells revealed microbial growth and skip wells which were erroneously interpreted by the Aris 2X instrument. Using manually interpreted BMD MICs read by two operators increased the overall categorical agreements to 88% and 95% compared to AD for colistin and 92% and 96% compared to AD for polymyxin B. Laboratories choosing to use the Sensititre platform for polymyxin AST should consider manual evaluation of wells as part of their algorithm.","journal":"Journal of Clinical Microbiology","year":2021,"id":186080,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9501,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":743345,"name":"Andrew E. Clark","orcid":"0000-0002-0722-0482","position":1,"is_corresponding":false},{"id":425339,"name":"Jung-Ho Youn","orcid":null,"position":2,"is_corresponding":false},{"id":744075,"name":"Rebecca A. Weingarten","orcid":null,"position":3,"is_corresponding":false},{"id":333884,"name":"Chelsea M. Crooks","orcid":"0000-0003-3874-4577","position":4,"is_corresponding":false},{"id":237087,"name":"John P. Dekker","orcid":"0000-0002-3701-5228","position":5,"is_corresponding":false},{"id":239663,"name":"Karen M. Frank","orcid":"0000-0002-9970-4133","position":6,"is_corresponding":false},{"id":316697,"name":"Michelle M. Bellerose","orcid":"0000-0003-0232-9953","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T23:48:42.632147Z","pmid":"34165324","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}