{"doi":"10.1128/jb.97.2.769-775.1969","title":"Relationships Between the Regulation of the Lactose and Galactose Operons of\n            <i>Escherichia coli</i>","abstract":"<jats:p>\n            A group of structurally related compounds, including galactose, fucose, and a number of galactosides, are regulatory effectors for both the\n            <jats:italic>lac</jats:italic>\n            and\n            <jats:italic>gal</jats:italic>\n            operons of\n            <jats:italic>Escherichia coli</jats:italic>\n            . Although a common set of effectors exists, each operon appears to be regulated independently of the other. Experiments with various regulatory mutants have shown, first, that the presence of the proteins of one operon is without effect on the regulation of the other and, second, that the influence an effector has on one operon is independent of the presence or the functional state of the regulatory genes of the other operon. It is unlikely, therefore, that the two operons share a common regulatory macromolecule. Both\n            <jats:italic>gal R</jats:italic>\n            <jats:sup>−</jats:sup>\n            and\n            <jats:italic>gal o</jats:italic>\n            <jats:sup>c</jats:sup>\n            regulatory mutants are equally resistant to repression by glucose and galactosides. It has been possible to show, in the\n            <jats:italic>gal</jats:italic>\n            operon, that induction and repression are competitive processes. For this operon, the differential rate of enzyme synthesis is set by the relative intracellular concentrations of inducer (fucose) and repressor (isopropylthiogalactoside).\n          </jats:p>","journal":"Journal of Bacteriology","year":1969,"id":14955,"datarank":1.047033623538495,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.717449936938062,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.717449936938062,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":7,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":115923,"name":"Kenneth Paigen","orcid":null,"position":1,"is_corresponding":false},{"id":115922,"name":"Beverly Williams","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4886293","pmcid":"PMC249758","openalex_id":"https://openalex.org/W1907183830","authors":[],"funders":[],"total_grants":0,"fwci":3.1468,"citation_percentile":0.90198535,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://jb.asm.org/content/jb/97/2/769.full.pdf","host_type":"journal"},{"url":"https://jb.asm.org/content/jb/97/2/769.full.pdf","host_type":"BRONZE"},{"url":"https://jb.asm.org/content/jb/97/2/769.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/jb.97.2.769-775.1969","host_type":"publisher"},{"url":"https://doi.org/10.1128/jb.97.2.769-775.1969","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/4886293","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/249758","host_type":"repository"}],"fields_of_study":["Bacterial Genetics and Biotechnology","Polyamine Metabolism and Applications","Amino Acid Enzymes and Metabolism","Biology","Medicine","Chemistry","Enzyme Induction","Enzyme Repression","Escherichia coli","Fucose","Galactose","Galactosidases","Glucose","Glycosides","Lactose","Molecular Biology","Mutation","Phosphotransferases"],"mesh_terms":["Enzyme Induction","Enzyme Repression","Escherichia coli","Fucose","Galactose","Galactosidases","Glucose","Glycosides","Lactose","Molecular Biology","Mutation","Phosphotransferases"],"keywords":["L-arabinose operon","Operon","gal operon","Biology","trp operon","lac operon","Inducer","Galactose","Effector","Escherichia coli","Lac repressor","Repressor","Mutant","Regulator gene","Biochemistry","Galactokinase","Galactosides","Fucose","Regulation of gene expression","Gene","Gene expression"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T15:44:14.508254Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}