{"doi":"10.1128/jb.187.15.5267-5277.2005","title":"Cystic Fibrosis Sputum Supports Growth and Cues Key Aspects of\n            <i>Pseudomonas aeruginosa</i>\n            Physiology","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            The opportunistic human pathogen\n            <jats:italic>Pseudomonas aeruginosa</jats:italic>\n            causes persistent airway infections in patients with cystic fibrosis (CF). To establish these chronic infections,\n            <jats:italic>P. aeruginosa</jats:italic>\n            must grow and proliferate within the highly viscous sputum in the lungs of CF patients. In this study, we used Affymetrix GeneChip microarrays to investigate the physiology of\n            <jats:italic>P. aeruginosa</jats:italic>\n            grown using CF sputum as the sole source of carbon and energy. Our results indicate that CF sputum readily supports high-density\n            <jats:italic>P. aeruginosa</jats:italic>\n            growth. Furthermore, multiple signals, which reduce swimming motility and prematurely activate the\n            <jats:italic>Pseudomonas</jats:italic>\n            quinolone signal cell-to-cell signaling cascade in\n            <jats:italic>P. aeruginosa</jats:italic>\n            , are present in CF sputum.\n            <jats:italic>P. aeruginosa</jats:italic>\n            factors critical for lysis of the common CF lung inhabitant\n            <jats:italic>Staphylococcus aureus</jats:italic>\n            were also induced in CF sputum and increased the competitiveness of\n            <jats:italic>P. aeruginosa</jats:italic>\n            during polymicrobial growth in CF sputum.\n          </jats:p>","journal":"Journal of Bacteriology","year":2005,"id":44360,"datarank":12.41479821675744,"base_score":6.049733455231958,"endowment":6.049733455231958,"self_citation_contribution":0.9074600182847938,"citation_network_contribution":11.507338198472645,"self_endowment_contribution":0.9074600182847938,"citer_contribution":11.507338198472645,"corpus_percentile":null,"corpus_rank":null,"citation_count":423,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":208979,"name":"Lauren M. Mashburn","orcid":null,"position":1,"is_corresponding":false},{"id":208980,"name":"Pradeep K. Singh","orcid":null,"position":2,"is_corresponding":false},{"id":208981,"name":"Marvin Whiteley","orcid":null,"position":3,"is_corresponding":false},{"id":208978,"name":"Kelli L. Palmer","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":6.049733455231958,"endowment":6.049733455231958,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16030221","pmcid":"PMC1196007","openalex_id":"https://openalex.org/W2154492506","authors":[],"funders":[{"funder_name":"NCRR NIH HHS","grant_id":"1P20RR1556401","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"P20 RR015564","title":null}],"total_grants":2,"fwci":4.9299,"citation_percentile":0.96032389,"influential_citations":27,"citation_trend":[{"year":2012,"count":15},{"year":2013,"count":16},{"year":2014,"count":32},{"year":2015,"count":25},{"year":2016,"count":26},{"year":2017,"count":23},{"year":2018,"count":24},{"year":2019,"count":21},{"year":2020,"count":22},{"year":2021,"count":42},{"year":2022,"count":29},{"year":2023,"count":20},{"year":2024,"count":18},{"year":2025,"count":13},{"year":2026,"count":3}],"oa_status":"green","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1196007","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc1196007?pdf=render","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1196007","host_type":"repository"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JB.187.15.5267-5277.2005","host_type":"publisher"},{"url":"https://doi.org/10.1128/jb.187.15.5267-5277.2005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16030221","host_type":"repository"}],"fields_of_study":["Bacterial biofilms and quorum sensing","Cystic Fibrosis Research Advances","Bacterial Genetics and Biotechnology","Medicine","Biology","Environmental Science","Culture Media","Cystic Fibrosis","Humans","Locomotion","Pseudomonas aeruginosa","Sputum"],"mesh_terms":["Culture Media","Cystic Fibrosis","Humans","Locomotion","Pseudomonas aeruginosa","Sputum"],"keywords":["Pseudomonas aeruginosa","Sputum","Cystic fibrosis","Microbiology","Biology","Pathogen","Staphylococcus aureus","Bacteria","Immunology","Pathology","Medicine","Tuberculosis","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-23T04:21:54.934692Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}