{"doi":"10.1128/jb.114.2.652-655.1973","title":"Cyclic Adenosine Monophosphate-Independent Mutants of the Lactose Operon of\n            <i>Escherichia coli</i>","abstract":"<jats:p>\n            In\n            <jats:italic>Escherichia coli</jats:italic>\n            the transcription of the lactose operon, like other catabolite-sensitive operons, requires catabolite gene activator protein and 3′,5′-cyclic adenosine monophosphate in addition to ribonucleic acid polymerase. We isolated and analyzed\n            <jats:italic>lac</jats:italic>\n            <jats:sup>+</jats:sup>\n            revertants from a\n            <jats:italic>crp</jats:italic>\n            <jats:sup>−</jats:sup>\n            strain of\n            <jats:italic>E. coli</jats:italic>\n            . We found that revertants with a higher level of expression only for the\n            <jats:italic>lac</jats:italic>\n            operon lie in the\n            <jats:italic>lac</jats:italic>\n            promoter region. These promoter mutations have no effect on operator or repressor function. Two of the revertants in which the lesions have been more precisely mapped carry mutations in the operator proximal segment of the promoter.\n          </jats:p>","journal":"Journal of Bacteriology","year":1973,"id":14852,"datarank":5.729353400677374,"base_score":3.828641396489095,"endowment":3.828641396489095,"self_citation_contribution":0.5742962094733643,"citation_network_contribution":5.155057191204009,"self_endowment_contribution":0.5742962094733643,"citer_contribution":5.155057191204009,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":45,"citers_with_citation_signal":43,"citers_with_endowment":43,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":115523,"name":"Terri Grodzicker","orcid":null,"position":1,"is_corresponding":false},{"id":115524,"name":"Jon Beckwith","orcid":null,"position":2,"is_corresponding":false},{"id":115522,"name":"Rita Arditti","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.828641396489095,"endowment":3.828641396489095,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4350344","pmcid":"PMC251822","openalex_id":"https://openalex.org/W1568136307","authors":[],"funders":[],"total_grants":0,"fwci":8.259,"citation_percentile":0.97306525,"influential_citations":1,"citation_trend":[{"year":2023,"count":1}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://jb.asm.org/content/jb/114/2/652.full.pdf","host_type":"journal"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC251822","host_type":"GREEN"},{"url":"https://jb.asm.org/content/jb/114/2/652.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/jb.114.2.652-655.1973","host_type":"publisher"},{"url":"https://doi.org/10.1128/jb.114.2.652-655.1973","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/4350344","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/251822","host_type":"repository"}],"fields_of_study":["Bacterial Genetics and Biotechnology","RNA and protein synthesis mechanisms","Genomics and Chromatin Dynamics","Biology","Medicine","Bacterial Proteins","Chromosome Mapping","Cyclic AMP","DNA-Directed RNA Polymerases","Escherichia coli","Galactosidases","Genes","Lactose","Mutagens","Mutation","Operon","Purines","Recombination, Genetic","Transcription, Genetic"],"mesh_terms":["Cyclic AMP","Bacterial Proteins","Chromosome Mapping","Escherichia coli","Galactosidases","Genes","Lactose","Mutagens","Mutation","Operon","Purines","Recombination, Genetic","DNA-Directed RNA Polymerases","Transcription, Genetic"],"keywords":["Operon","Catabolite repression","lac operon","Lac repressor","gal operon","L-arabinose operon","Biology","trp operon","Repressor","Escherichia coli","Molecular biology","Activator (genetics)","Mutant","Biochemistry","Transcription (linguistics)","Gene","Gene expression"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T15:06:00.026422Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}