{"doi":"10.1128/jb.112.3.1184-1192.1972","title":"Polycistronic Effects of Catabolite Repression on the\n            <i>lac</i>\n            Operon","abstract":"<jats:p>\n            The catabolite repression caused by glucose and glucose-6-phosphate has been studied for both β-galactosidase and thiogalactoside transacetylase, the products of the operator proximal and distal cistrons of the\n            <jats:italic>lac</jats:italic>\n            operon, respectively. We find that both cistrons are affected coordinately by this form of repression. We also find that a single alteration at the\n            <jats:italic>lac</jats:italic>\n            promoter region is sufficient to abolish sensitivity to repression of both cistrons. From this, we conclude that there is only one target site for catabolite repression in the\n            <jats:italic>lac</jats:italic>\n            operon.\n          </jats:p>","journal":"Journal of Bacteriology","year":1972,"id":15577,"datarank":0.6346736069865841,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.3050899203861512,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.3050899203861512,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":6,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":118403,"name":"Boris Magasanik","orcid":null,"position":1,"is_corresponding":false},{"id":118402,"name":"Allen E. Silverstone","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4118294","pmcid":"PMC251547","openalex_id":"https://openalex.org/W1910000392","authors":[],"funders":[],"total_grants":0,"fwci":1.3961,"citation_percentile":0.78496262,"influential_citations":0,"citation_trend":[{"year":2021,"count":1}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://jb.asm.org/content/jb/112/3/1184.full.pdf","host_type":"journal"},{"url":"https://jb.asm.org/content/jb/112/3/1184.full.pdf","host_type":"BRONZE"},{"url":"https://jb.asm.org/content/jb/112/3/1184.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/jb.112.3.1184-1192.1972","host_type":"publisher"},{"url":"https://doi.org/10.1128/jb.112.3.1184-1192.1972","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/4118294","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/251547","host_type":"repository"}],"fields_of_study":["Glycosylation and Glycoproteins Research","Carbohydrate Chemistry and Synthesis","Enzyme Structure and Function","Biology","Medicine","Acetyltransferases","Chloramphenicol","Chromosome Mapping","Chromosomes, Bacterial","Coliphages","Dactinomycin","Edetic Acid","Enzyme Induction","Enzyme Repression","Escherichia coli","Galactose","Galactosidases","Glucose","Glucosephosphates","Glycosides","Lactose","Operon","Protein Biosynthesis","RNA, Messenger","Rifampin","Transcription, Genetic","Transduction, Genetic","Tryptophan"],"mesh_terms":["Acetyltransferases","Chloramphenicol","Chromosome Mapping","Chromosomes, Bacterial","Coliphages","Dactinomycin","Edetic Acid","Enzyme Induction","Enzyme Repression","Escherichia coli","Galactose","Galactosidases","Glucose","Glucosephosphates","Glycosides","Lactose","Operon","Rifampin","RNA, Messenger","Transcription, Genetic","Transduction, Genetic","Protein Biosynthesis","Tryptophan"],"keywords":["Catabolite repression","lac operon","Operon","Psychological repression","Fed-batch culture","Biology","L-arabinose operon","Enzyme Repression","Repressor","gal operon","Lac repressor","Biochemistry","Genetics","Gene","Plasmid","Gene expression","Escherichia coli"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Peace, Justice and strong institutions"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T18:14:37.525704Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}