{"doi":"10.1128/jb.102.3.672-676.1970","title":"Synergism Between Cysteine and Alkylating Agents","abstract":"<jats:p>\n            Contrary to expectation,\n            <jats:sc>l</jats:sc>\n            -cysteine did not protect\n            <jats:italic>Escherichia coli</jats:italic>\n            from the lethal action of two monofunctional alkylating agents (nitrosomethylurethane and methylmethane sulfonate). The antibacterial action of these compounds was actually greatly enhanced by\n            <jats:sc>l</jats:sc>\n            -cysteine. This synergistic effect was also exhibited, to some extent, by\n            <jats:sc>d</jats:sc>\n            -cysteine but not by homocysteine,\n            <jats:italic>S</jats:italic>\n            -methylcysteine, or serine. The synergistic action between methylating agents and\n            <jats:sc>l</jats:sc>\n            -cysteine was not due to the formation of\n            <jats:italic>S</jats:italic>\n            -methylcysteine.\n            <jats:sc>l</jats:sc>\n            -Cysteine had no effect on the bacteriostatic action of ethylmethane sulfonate.\n          </jats:p>","journal":"Journal of Bacteriology","year":1970,"id":634028,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1644158,"name":"Howard S. Carr","orcid":null,"position":1,"is_corresponding":false},{"id":1644159,"name":"Jack Zyroff","orcid":null,"position":2,"is_corresponding":false},{"id":1644157,"name":"Herbert S. Rosenkranz","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Synergism Between Cysteine and Alkylating Agents","abstract":"<jats:p>\n            Contrary to expectation,\n            <jats:sc>l</jats:sc>\n            -cysteine did not protect\n            <jats:italic>Escherichia coli</jats:italic>\n            from the lethal action of two monofunctional alkylating agents (nitrosomethylurethane and methylmethane sulfonate). The antibacterial action of these compounds was actually greatly enhanced by\n            <jats:sc>l</jats:sc>\n            -cysteine. This synergistic effect was also exhibited, to some extent, by\n            <jats:sc>d</jats:sc>\n            -cysteine but not by homocysteine,\n            <jats:italic>S</jats:italic>\n            -methylcysteine, or serine. The synergistic action between methylating agents and\n            <jats:sc>l</jats:sc>\n            -cysteine was not due to the formation of\n            <jats:italic>S</jats:italic>\n            -methylcysteine.\n            <jats:sc>l</jats:sc>\n            -Cysteine had no effect on the bacteriostatic action of ethylmethane sulfonate.\n          </jats:p>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4914073","pmcid":null,"openalex_id":"https://openalex.org/W2168236782","authors":[],"funders":[],"total_grants":0,"fwci":0.5952,"citation_percentile":0.71162075,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://jb.asm.org/content/jb/102/3/672.full.pdf","host_type":"journal"},{"url":"https://jb.asm.org/content/jb/102/3/672.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/jb.102.3.672-676.1970","host_type":"publisher"},{"url":"https://doi.org/10.1128/jb.102.3.672-676.1970","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/4914073","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC247611","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/247611","host_type":"repository"}],"fields_of_study":["Biopolymer Synthesis and Applications","Antimicrobial agents and applications","Alkanes","Alkylating Agents","Anti-Bacterial Agents","Cysteine","Drug Resistance, Microbial","Drug Synergism","Escherichia coli","Homocysteine","Nitroso Compounds","Serine","Stereoisomerism","Sulfonic Acids","Urethane"],"mesh_terms":["Alkanes","Alkylating Agents","Anti-Bacterial Agents","Cysteine","Drug Resistance, Microbial","Drug Synergism","Escherichia coli","Homocysteine","Nitroso Compounds","Serine","Stereoisomerism","Sulfonic Acids","Urethane"],"keywords":["Cysteine","Serine","Escherichia coli","Biology","Biochemistry","Methyl methanesulfonate","Homocysteine","DNA","DNA repair","Enzyme","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T13:02:23.758121Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}