{"doi":"10.1128/jb.00574-18","title":"Inactivation of the Monofunctional Peptidoglycan Glycosyltransferase SgtB Allows\n                    <i>Staphylococcus aureus</i>\n                    To Survive in the Absence of Lipoteichoic Acid","abstract":"<jats:p>\n                    The bacterial cell wall acts as a primary defense against environmental insults such as changes in osmolarity. It is also a vulnerable structure, as defects in its synthesis can lead to growth arrest or cell death. The important human pathogen\n                    <jats:named-content content-type=\"genus-species\">Staphylococcus aureus</jats:named-content>\n                    has a typical Gram-positive cell wall, which consists of peptidoglycan and the anionic polymers LTA and wall teichoic acid. Several clinically relevant antibiotics inhibit the synthesis of peptidoglycan; therefore, it and teichoic acids are considered attractive targets for the development of new antimicrobials. We show that LTA is required for efficient peptidoglycan cross-linking in\n                    <jats:named-content content-type=\"genus-species\">S. aureus</jats:named-content>\n                    and inactivation of a peptidoglycan glycosyltransferase can partially rescue this defect, together revealing an intimate link between peptidoglycan and LTA synthesis.\n                  </jats:p>","journal":"Journal of Bacteriology","year":2019,"id":628470,"datarank":0.5837730447165941,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"self_citation_contribution":0.5837730447165941,"citation_network_contribution":0.0,"self_endowment_contribution":0.5837730447165941,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":461721,"name":"Christopher F. 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It is also a vulnerable structure, as defects in its synthesis can lead to growth arrest or cell death. The important human pathogen\n                    <jats:named-content content-type=\"genus-species\">Staphylococcus aureus</jats:named-content>\n                    has a typical Gram-positive cell wall, which consists of peptidoglycan and the anionic polymers LTA and wall teichoic acid. Several clinically relevant antibiotics inhibit the synthesis of peptidoglycan; therefore, it and teichoic acids are considered attractive targets for the development of new antimicrobials. We show that LTA is required for efficient peptidoglycan cross-linking in\n                    <jats:named-content content-type=\"genus-species\">S. aureus</jats:named-content>\n                    and inactivation of a peptidoglycan glycosyltransferase can partially rescue this defect, together revealing an intimate link between peptidoglycan and LTA synthesis.\n                  </jats:p>","is_dataset_classified":null,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30322854","pmcid":"PMC6287468","openalex_id":"https://openalex.org/W2951131666","authors":[],"funders":[{"funder_name":"European Research Council","grant_id":"260371","title":"A functional analysis of Listeria and Staphylococcus lipoteichoic acid"},{"funder_name":"Wellcome Trust","grant_id":"100289","title":"Deciphering the nucleotide signalling network of the Gram-positive 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