{"doi":"10.1128/jb.00416-22","title":"A Survey of Two-Component Systems in Coxiella burnetii Reveals Redundant Regulatory Schemes and a Requirement for an Atypical PhoBR System in Mammalian Cell Infection","abstract":"C. burnetii is an obligate intracellular bacterium with a spore-like stability allowing it to survive long periods of time in the environment. This stability is likely due to its biphasic developmental cycle, whereby it can transition from an environmentally stable small-cell variant (SCV) to a metabolically active large-cell variant (LCV). Here, we define the role of two-component phosphorelay systems (TCS) in C. burnetii's ability to survive within the harsh environment contained in the phagolysosome of host cells. We show that the canonical PhoBR TCS has an important role in C. burnetii virulence and phosphate sensing. Further examination of the regulons controlled by orphan regulators indicated a role in modulating gene expression of SCV-associated genes, including genes essential for cell wall remodeling.","journal":"Journal of Bacteriology","year":2023,"id":360289,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":690545,"name":"C. L. Larson","orcid":"0000-0002-0924-0604","position":1,"is_corresponding":false},{"id":260433,"name":"Kimmo Virtaneva","orcid":"0000-0002-5503-1483","position":2,"is_corresponding":false},{"id":269192,"name":"Kishore Kanakabandi","orcid":null,"position":3,"is_corresponding":false},{"id":911428,"name":"Benjamin P. Darwitz","orcid":"0000-0002-0936-384X","position":4,"is_corresponding":false},{"id":1112141,"name":"Ben Crews","orcid":null,"position":5,"is_corresponding":false},{"id":1112142,"name":"Keelee Storrud","orcid":null,"position":6,"is_corresponding":false},{"id":303822,"name":"Robert A. Heinzen","orcid":"0000-0001-6870-4619","position":7,"is_corresponding":false},{"id":303814,"name":"Paul A. Beare","orcid":"0000-0002-2282-177X","position":8,"is_corresponding":false},{"id":515537,"name":"Shaun Wachter","orcid":null,"position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-19T01:14:01.896928Z","pmid":"36847507","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}