{"doi":"10.1128/jb.00392-22","title":"Staphylococcus aureus SigS Induces Expression of a Regulatory Protein Pair That Modulates Its mRNA Stability","abstract":"SigS is necessary for S. aureus virulence, immune evasion, and adaptation to chemical and environmental stressors. These processes are critically important for the ability of S. aureus to cause disease. However, the SigS-dependent transcriptome has not been identified, hindering our ability to identify downstream effectors of SigS that contribute to these pathogenic and adaptive phenotypes. Here, we identify a regulatory protein pair that is a major direct target of SigS, known as SroA and SroB. SroA also acts to stimulate SigS expression at the posttranscriptional level of RNA turnover, providing insight into intrinsically low levels of SigS. The discovery of SroA and SroB increases our understanding of SigS and the S. aureus pathogenesis process.","journal":"Journal of Bacteriology","year":2023,"id":374841,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1010383,"name":"Jamilah Alsulami","orcid":null,"position":1,"is_corresponding":false},{"id":795274,"name":"Joseph I Aubee","orcid":"0000-0003-2849-296X","position":2,"is_corresponding":false},{"id":951470,"name":"Ayotimofe Idowu","orcid":null,"position":3,"is_corresponding":false},{"id":573658,"name":"Brooke R. Tomlinson","orcid":"0000-0001-6561-7931","position":4,"is_corresponding":false},{"id":1010384,"name":"Emily A. Felton","orcid":null,"position":5,"is_corresponding":false},{"id":979810,"name":"Jessica K. Jackson","orcid":"0000-0001-7206-6170","position":6,"is_corresponding":false},{"id":1136783,"name":"Sarah J. Kennedy","orcid":"0009-0001-6715-7585","position":7,"is_corresponding":false},{"id":1136784,"name":"Nathanial Torres","orcid":"0000-0002-7594-2866","position":8,"is_corresponding":false},{"id":398224,"name":"Lindsey N. Shaw","orcid":"0000-0002-0629-8990","position":9,"is_corresponding":false},{"id":795275,"name":"Karl M. Thompson","orcid":"0000-0001-6182-9507","position":10,"is_corresponding":false},{"id":1009905,"name":"Amer Al Ali","orcid":"0000-0002-4189-4800","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T01:16:15.380731Z","pmid":"37255480","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}