{"doi":"10.1128/jb.00390-22","title":"A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes","abstract":"Copper is a frontline antimicrobial used to limit bacterial growth in multiple settings. Here, we demonstrate how the response regulator CopR from a plasmid-borne two-component system in the opportunistic pathogen L. monocytogenes directly induces lipoprotein remodeling in tandem with copper resistance genes due to extracellular copper stress. Activation of CopR by phosphorylation converts the lipoprotein chemotype from a high- to low-immunostimulatory TLR2 ligand. The two-component system-mediated coregulation of copper resistance determinants, in tandem with lipoprotein biosynthesis demonstrated here in L. monocytogenes, may be a common feature of transmissible copper resistance cassettes found in other Firmicutes.","journal":"Journal of Bacteriology","year":2023,"id":380496,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9563,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":244128,"name":"Amena A. Rizk","orcid":null,"position":1,"is_corresponding":false},{"id":385423,"name":"Krista M. Armbruster","orcid":"0000-0002-5252-8793","position":2,"is_corresponding":false},{"id":1145888,"name":"Victoria A. Bonnell","orcid":"0000-0003-1789-8067","position":3,"is_corresponding":false},{"id":245298,"name":"Manuel Llinás","orcid":"0000-0002-6173-5882","position":4,"is_corresponding":false},{"id":385424,"name":"Timothy C. Meredith","orcid":"0000-0002-1901-6841","position":5,"is_corresponding":false},{"id":386538,"name":"Gloria Komazin","orcid":null,"position":0,"is_corresponding":true}],"reference_count":87,"raw_metadata":null,"created_at":"2026-07-19T01:17:04.905707Z","pmid":"36622228","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}