{"doi":"10.1128/jb.00321-15","title":"Secreted Cyclic Di-GMP Induces Stalk Cell Differentiation in the Eukaryote Dictyostelium discoideum","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            Cyclic di-GMP (c-di-GMP) is currently recognized as the most widely used intracellular signal molecule in prokaryotes, but roles in eukaryotes were only recently discovered. In the social amoeba\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Dictyostelium discoideum</jats:named-content>\n            , c-di-GMP, produced by a prokaryote-type diguanylate cyclase, induces the differentiation of stalk cells, thereby enabling the formation of spore-bearing fruiting bodies. In this review, we summarize the currently known mechanisms that control the major life cycle transitions of\n            <jats:named-content xmlns:xlink=\"http://www.w3.org/1999/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Dictyostelium</jats:named-content>\n            and focus particularly on the role of c-di-GMP in stalk formation. Stalk cell differentiation has characteristics of autophagic cell death, a process that also occurs in higher eukaryotes. We discuss the respective roles of c-di-GMP and of another signal molecule, differentiation-inducing factor 1, in autophagic cell death\n            <jats:italic>in vitro</jats:italic>\n            and in stalk formation\n            <jats:italic>in vivo</jats:italic>\n            .\n          </jats:p>","journal":"Journal of Bacteriology","year":2016,"id":39921,"datarank":0.8977539227175917,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.4210458481653998,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.4210458481653998,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":23,"citers_with_citation_signal":14,"citers_with_endowment":14,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":194951,"name":"Pauline Schaap","orcid":null,"position":1,"is_corresponding":false},{"id":194950,"name":"Zhi-hui Chen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26013485","pmcid":"PMC4686194","openalex_id":"https://openalex.org/W1574213181","authors":[],"funders":[{"funder_name":"The Leverhulme Trust","grant_id":"RPG-2012-746","title":null},{"funder_name":"Wellcome Trust","grant_id":"100293/Z/12/Z","title":null},{"funder_name":"Wellcome Trust","grant_id":"100293","title":"Molecular mechanisms of encystation and sporulation."},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"BB/K000799/1","title":null}],"total_grants":4,"fwci":0.7531,"citation_percentile":0.71042954,"influential_citations":0,"citation_trend":[{"year":2016,"count":2},{"year":2018,"count":3},{"year":2019,"count":4},{"year":2021,"count":1},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":7},{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://jb.asm.org/content/jb/198/1/27.full.pdf","host_type":"journal"},{"url":"https://jb.asm.org/content/jb/198/1/27.full.pdf","host_type":"HYBRID"},{"url":"https://jb.asm.org/content/jb/198/1/27.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JB.00321-15","host_type":"publisher"},{"url":"https://doi.org/10.1128/jb.00321-15","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26013485","host_type":"repository"},{"url":"https://discovery.dundee.ac.uk/en/publications/02ccfffd-99d9-4350-9818-231c06c1e97a","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4686194","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4686194","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4686194?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1128/JB.00321-15","host_type":""},{"url":"https://dx.doi.org/10.1128/jb.00321-15","host_type":""},{"url":"https://doi.org/https://doi.org/10.1128/JB.00321-15","host_type":""}],"fields_of_study":["Protist diversity and phylogeny","Cellular Mechanics and Interactions","Bacterial biofilms and quorum sensing","Medicine","Biology","Chemistry","0301 basic medicine","0303 health sciences","03 medical and health sciences","Cyclic GMP","Dictyostelium","Signal Transduction","Spores, Protozoan"],"mesh_terms":["Dictyostelium","Cyclic GMP","Signal Transduction","Spores, Protozoan"],"keywords":["Dictyostelium discoideum","Biology","Dictyostelium","Eukaryote","Cell biology","Amoeba (genus)","Slime mold","Stalk","Mycetozoa","Cellular differentiation","Intracellular","Cytokinesis","Programmed cell death","Cell division","Cell","Biochemistry","Gene","570","/dk/atira/pure/subjectarea/asjc/1300/1312","/dk/atira/pure/subjectarea/asjc/2400/2404","Spores, Protozoan","name=Molecular Biology","612","name=Microbiology","Cyclic GMP","Meeting Reviews","Signal Transduction"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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