{"doi":"10.1128/jb.00312-20","title":"Two Signal Recognition Particle Sequences Are Present in the Amino-Terminal Domain of the C-Tailed Protein SciP","abstract":"<jats:p>C-tail proteins are anchored in the inner membrane with a transmembrane segment at the C terminus in an N-in/C-out topology. Due to this topology, membrane insertion occurs only posttranslationally. Nevertheless, the C-tail-anchored protein SciP is targeted cotranslationally by SRP. We report here that two amino-terminal hydrophobic stretches in SciP are individually recognized by SRP and target the nascent protein to FtsY. The presence of two signal sequences may enable a retargeting mechanism, as already observed for multispanning membrane proteins, to make the posttranslational insertion of SciP by YidC more efficient.</jats:p>","journal":"Journal of Bacteriology","year":2020,"id":37043,"datarank":0.23386148226899717,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.025917328101013562,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.025917328101013562,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":186463,"name":"Andreas Kuhn","orcid":null,"position":1,"is_corresponding":false},{"id":186462,"name":"Eva Pross","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33020223","pmcid":"PMC7723959","openalex_id":"https://openalex.org/W3091744212","authors":[],"funders":[{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"KU749/5","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"}],"total_grants":2,"fwci":0.1667,"citation_percentile":0.50853101,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":1},{"year":2025,"count":1}],"oa_status":"green","license":"ASM Journals Non-Commercial TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7723959","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723959","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7723959","host_type":"repository"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JB.00312-20","host_type":"publisher"},{"url":"https://doi.org/10.1128/jb.00312-20","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33020223","host_type":"repository"},{"url":"https://dx.doi.org/10.1128/jb.00312-20","host_type":""}],"fields_of_study":["RNA and protein synthesis mechanisms","Bacterial Genetics and Biotechnology","Bacteriophages and microbial interactions","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Amino Acid Sequence","Escherichia coli","Hydrophobic and Hydrophilic Interactions","Mutation","Octamer Transcription Factor-6","Signal Recognition Particle"],"mesh_terms":["Amino Acid Sequence","Escherichia coli","Mutation","Signal Recognition Particle","Octamer Transcription Factor-6","Hydrophobic and Hydrophilic Interactions"],"keywords":["Biology","Signal recognition particle","Terminal (telecommunication)","Domain (mathematical analysis)","SIGNAL (programming language)","Protein domain","Amino terminal","Peptide sequence","Particle (ecology)","Computational biology","Sequence (biology)","Bacterial protein","Genetics","Signal peptide","Gene","Computer science","Telecommunications","Protein folding","Protein Sorting","Signal Sequences","C-tailed Protein","Membrane Protein Targeting","Mutation","Escherichia coli","Octamer Transcription Factor-6","Amino Acid Sequence","Hydrophobic and Hydrophilic Interactions"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-10T18:15:06.891877Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}