{"doi":"10.1128/jb.00144-22","title":"Discovery of a Novel Inner Membrane-Associated Bacterial Structure Related to the Flagellar Type III Secretion System","abstract":"The type III secretion system (T3SS) is a fascinating suite of proteins involved in building diverse macromolecular systems, including the bacterial flagellar motility machine, the injectisome machinery that bacteria use to inject effector proteins into host cells, and probably membrane nanotubes which connect bacterial cells. Here, we accidentally discovered a novel inner membrane-associated complex related to the flagellar T3SS. Examining our lab database, which is comprised of more than 40,000 cryo-tomograms of dozens of species, we discovered that this novel structure is both ubiquitous and ancient, being present in highly divergent classes of bacteria. Discovering a novel, widespread structure related to what are among the best-studied molecular machines in bacteria will open new venues for research aiming at understanding the function and evolution of T3SS proteins.","journal":"Journal of Bacteriology","year":2022,"id":274202,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":667972,"name":"Catherine M. Oikonomou","orcid":"0000-0003-2312-4746","position":1,"is_corresponding":false},{"id":390098,"name":"Cecily R. Wood","orcid":"0000-0003-1259-3862","position":2,"is_corresponding":false},{"id":270514,"name":"Georges Chreifi","orcid":"0000-0003-4194-1694","position":3,"is_corresponding":false},{"id":346090,"name":"Debnath Ghosal","orcid":"0000-0002-2227-0330","position":4,"is_corresponding":false},{"id":667973,"name":"Megan J. Dobro","orcid":"0000-0002-6464-3932","position":5,"is_corresponding":false},{"id":557870,"name":"Qing Yao","orcid":"0000-0003-3575-9909","position":6,"is_corresponding":false},{"id":942278,"name":"Ritesh Ranjan Pal","orcid":"0000-0002-7513-6792","position":7,"is_corresponding":false},{"id":942279,"name":"Amit K. Baidya","orcid":"0000-0002-2472-3719","position":8,"is_corresponding":false},{"id":942280,"name":"Yuxi Liu","orcid":"0000-0001-9658-0668","position":9,"is_corresponding":false},{"id":942281,"name":"Stefano Maggi","orcid":"0000-0003-4853-5840","position":10,"is_corresponding":false},{"id":754131,"name":"Alasdair W. McDowall","orcid":null,"position":11,"is_corresponding":false},{"id":942282,"name":"Sigal Ben‐Yehuda","orcid":"0000-0001-7023-2163","position":12,"is_corresponding":false},{"id":740977,"name":"Ilan Rosenshine","orcid":"0000-0001-7396-3586","position":13,"is_corresponding":false},{"id":401780,"name":"Ariane Briegel","orcid":"0000-0003-3733-3725","position":14,"is_corresponding":false},{"id":302906,"name":"Morgan Beeby","orcid":"0000-0001-6413-9835","position":15,"is_corresponding":false},{"id":270511,"name":"Yi‐Wei Chang","orcid":"0000-0003-2391-473X","position":16,"is_corresponding":false},{"id":390104,"name":"Carrie L. Shaffer","orcid":"0000-0002-7457-7422","position":17,"is_corresponding":false},{"id":44863,"name":"Grant J. Jensen","orcid":"0000-0003-1556-4864","position":18,"is_corresponding":false},{"id":330697,"name":"Mohammed Kaplan","orcid":"0000-0002-0759-0459","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T00:28:07.776043Z","pmid":"35862756","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}