{"doi":"10.1128/jb.00105-21","title":"Bacterial Cytological Profiling Identifies Rhodanine-Containing PAINS Analogs as Specific Inhibitors of <i>Escherichia coli</i> Thymidylate Kinase <i>In Vivo</i>","abstract":"We demonstrate that bacterial cytological profiling is a powerful tool for directing antibiotic discovery efforts because it can be used to determine the specificity of an antibiotic’s in vivo mechanism of action. By assaying analogs of PAINS, molecules that are notoriously intractable and nonspecific, we (surprisingly) identify molecules with specific activity against E. coli thymidylate kinase.","journal":"Journal of Bacteriology","year":2021,"id":182813,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":460235,"name":"Jason F. Nideffer","orcid":null,"position":1,"is_corresponding":false},{"id":459024,"name":"Joseph Sugie","orcid":"0000-0003-2911-1807","position":2,"is_corresponding":false},{"id":735343,"name":"Eray Enüstün","orcid":"0000-0001-7550-7752","position":3,"is_corresponding":false},{"id":735344,"name":"Adam B. Shapiro","orcid":"0000-0002-2662-6146","position":4,"is_corresponding":false},{"id":442184,"name":"Hannah Tsunemoto","orcid":"0000-0002-1546-097X","position":5,"is_corresponding":false},{"id":735345,"name":"Alan I. Derman","orcid":"0009-0006-2631-3074","position":6,"is_corresponding":false},{"id":261965,"name":"Kit Pogliano","orcid":"0000-0002-7868-3345","position":7,"is_corresponding":false},{"id":244710,"name":"Joe Pogliano","orcid":"0000-0001-8989-2655","position":8,"is_corresponding":false},{"id":735342,"name":"Elizabeth T. Montaño","orcid":"0000-0003-3688-5616","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-18T23:48:13.605421Z","pmid":"34280002","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}