{"doi":"10.1128/jb.00071-19","title":"The Two Chemotaxis Clusters in Caulobacter crescentus Play Different Roles in Chemotaxis and Biofilm Regulation","abstract":"<jats:p>\n                    Chemosensory systems constitute major signal transduction pathways in bacteria. These systems are involved in chemotaxis and other cell responses to environment conditions, such as the production of adhesins to enable irreversible adhesion to a surface and surface colonization. The\n                    <jats:named-content content-type=\"genus-species\">C. crescentus</jats:named-content>\n                    genome encodes two complete chemotaxis clusters. Here, we characterized the second novel chemotaxis-like cluster. While only the major chemotaxis cluster is involved in chemotaxis, both chemotaxis systems modulate\n                    <jats:named-content content-type=\"genus-species\">C. crescentus</jats:named-content>\n                    adhesion by controlling expression of the holdfast synthesis inhibitor HfiA. Here, we identify a new level in holdfast regulation, providing new insights into the control of adhesin production that leads to the formation of biofilms in response to the environment.\n                  </jats:p>","journal":"Journal of Bacteriology","year":2019,"id":686915,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":278676,"name":"Yves V. Brun","orcid":"0000-0002-9289-1909","position":1,"is_corresponding":false},{"id":916502,"name":"Cécile Berne","orcid":"0000-0003-3731-9317","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Two Chemotaxis Clusters in Caulobacter crescentus Play Different Roles in Chemotaxis and Biofilm Regulation","abstract":"<jats:p>\n                    Chemosensory systems constitute major signal transduction pathways in bacteria. These systems are involved in chemotaxis and other cell responses to environment conditions, such as the production of adhesins to enable irreversible adhesion to a surface and surface colonization. The\n                    <jats:named-content content-type=\"genus-species\">C. crescentus</jats:named-content>\n                    genome encodes two complete chemotaxis clusters. Here, we characterized the second novel chemotaxis-like cluster. While only the major chemotaxis cluster is involved in chemotaxis, both chemotaxis systems modulate\n                    <jats:named-content content-type=\"genus-species\">C. crescentus</jats:named-content>\n                    adhesion by controlling expression of the holdfast synthesis inhibitor HfiA. Here, we identify a new level in holdfast regulation, providing new insights into the control of adhesin production that leads to the formation of biofilms in response to the environment.\n                  </jats:p>","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31109992","pmcid":"PMC6707910","openalex_id":"https://openalex.org/W2945367020","authors":[],"funders":[{"funder_name":"HHS | National Institutes of Health","grant_id":"R35GM122556","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R35GM122556-03","title":"Bacterial Subcellular Organization and its Impact on Growth, Development, Aging, and Surface Adhesion"}],"total_grants":2,"fwci":1.1358,"citation_percentile":0.7720899,"influential_citations":0,"citation_trend":[{"year":2018,"count":2},{"year":2020,"count":4},{"year":2021,"count":4},{"year":2022,"count":7},{"year":2023,"count":7},{"year":2024,"count":8},{"year":2025,"count":2},{"year":2026,"count":6}],"oa_status":"green","license":"ASM Journals Non-Commercial TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6707910","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6707910","host_type":"repository"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JB.00071-19","host_type":"publisher"},{"url":"https://doi.org/10.1128/jb.00071-19","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31109992","host_type":"repository"},{"url":"https://jb.asm.org/content/jb/201/18/e00071-19.full.pdf","host_type":""},{"url":"https://dx.doi.org/10.1128/jb.00071-19","host_type":""}],"fields_of_study":["Bacterial biofilms and quorum sensing","Biochemical and Structural Characterization","Vibrio bacteria research studies","0301 basic medicine","03 medical and health sciences","Bacterial Adhesion","Bacterial Proteins","Biofilms","Caulobacter crescentus","Chemotaxis","Cluster Analysis","Gene Expression Regulation, Bacterial","Mutation"],"mesh_terms":["Bacterial Adhesion","Bacterial Proteins","Chemotaxis","Mutation","Gene Expression Regulation, Bacterial","Cluster Analysis","Caulobacter crescentus","Biofilms"],"keywords":["Caulobacter crescentus","Chemotaxis","Holdfast","Biology","Cell biology","Flagellum","Bacterial adhesin","Microbiology","Genetics","Gene","Receptor","Cell cycle","Escherichia coli","biofilms","Bacterial Adhesion","Bacterial Proteins","Mutation","Cluster Analysis","Gene Expression Regulation, Bacterial"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T20:48:53.104774Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}