{"doi":"10.1128/iai.00809-20","title":"TLR4-Endothelin Axis Controls Syncytiotrophoblast Motility and Confers Fetal Protection in Placental Malaria","abstract":"-infected erythrocytes was dependent on TLR4 via the TRIF pathway but not MyD88 signaling. Time-lapse microscopy in syncytiotrophoblast primary cultures and cell invasion assays demonstrated that ablation of TLR4 or endothelin receptor blockade abrogates trophoblast collective motility and cell migration responses to infected erythrocytes. These results cohesively substantiate the hypothesis that fetal innate immune sensing, namely, the TRL4-TRIF pathway, exerts a fetal protective role during malaria infection by mediating syncytiotrophoblast vasoregulatory responses that counteract placental insufficiency.","journal":"Infection and Immunity","year":2021,"id":206703,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":791652,"name":"Alexander Marta","orcid":null,"position":1,"is_corresponding":false},{"id":791148,"name":"André Barateiro","orcid":"0000-0002-2280-6991","position":2,"is_corresponding":false},{"id":791149,"name":"Carla Letícia Bandeira","orcid":"0000-0002-0796-3462","position":3,"is_corresponding":false},{"id":791150,"name":"Jamille Gregório Dombrowski","orcid":"0000-0002-1863-1914","position":4,"is_corresponding":false},{"id":791151,"name":"João Costa","orcid":"0000-0003-3590-5849","position":5,"is_corresponding":false},{"id":791152,"name":"Cláudio Romero Farias Marinho","orcid":"0000-0002-1227-3845","position":6,"is_corresponding":false},{"id":791153,"name":"Carlos Penha‐Gonçalves","orcid":"0000-0001-7225-1907","position":7,"is_corresponding":false},{"id":791147,"name":"Yash Pandya","orcid":"0000-0002-2302-9282","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-18T23:51:41.571653Z","pmid":"34061587","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}