{"doi":"10.1128/iai.00369-19","title":"Protective Role of Kupffer Cells and Macrophages in Klebsiella pneumoniae-Induced Liver Abscess Disease","abstract":"<jats:p><jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae</jats:named-content>-induced liver abscess (KLA) is emerging as a leading cause of pyogenic liver abscess worldwide. In recent years, the emergence of hypervirulent<jats:named-content content-type=\"genus-species\">K. pneumoniae</jats:named-content>(hvKp) has been strongly associated with KLA. Unlike classical<jats:named-content content-type=\"genus-species\">K. pneumoniae</jats:named-content>, which generally infects the immunocompromised population, hvKp can cause serious and invasive infections in young and healthy individuals. hvKp isolates are often associated with the K1/K2 capsular types and possess hypermucoviscous capsules.</jats:p>","journal":"Infection and Immunity","year":2019,"id":611872,"datarank":0.5533319181170905,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"self_citation_contribution":0.5533319181170905,"citation_network_contribution":0.0,"self_endowment_contribution":0.5533319181170905,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":877637,"name":"Yi Han Tan","orcid":"0000-0002-2461-1901","position":1,"is_corresponding":false},{"id":1575124,"name":"Yunn-Hwen Gan","orcid":null,"position":2,"is_corresponding":false},{"id":1575123,"name":"Chu Han Hoh","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Protective Role of Kupffer Cells and Macrophages in Klebsiella pneumoniae-Induced Liver Abscess Disease","abstract":"<jats:p><jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae</jats:named-content>-induced liver abscess (KLA) is emerging as a leading cause of pyogenic liver abscess worldwide. In recent years, the emergence of hypervirulent<jats:named-content content-type=\"genus-species\">K. pneumoniae</jats:named-content>(hvKp) has been strongly associated with KLA. Unlike classical<jats:named-content content-type=\"genus-species\">K. pneumoniae</jats:named-content>, which generally infects the immunocompromised population, hvKp can cause serious and invasive infections in young and healthy individuals. hvKp isolates are often associated with the K1/K2 capsular types and possess hypermucoviscous capsules.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31285251","pmcid":"PMC6704610","openalex_id":null,"authors":[],"funders":[{"funder_name":"National University Health System","grant_id":"NUHSRO/2014/068/AF New Idea/03","title":null},{"funder_name":"National University of Singapore","grant_id":"iHealthTech Microbiome Seed grant 2018","title":null}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://iai.asm.org/content/iai/87/9/e00369-19.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/IAI.00369-19","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6704610","host_type":"repository"}],"fields_of_study":[],"mesh_terms":["Macrophages","Kupffer Cells","Animals","Mice, Inbred C57BL","Mice","Klebsiella pneumoniae","Klebsiella Infections","Liver Abscess","Bacterial Capsules","Virulence Factors","Virulence"],"keywords":["Macrophages","Kupffer cells","Klebsiella pneumoniae","Liver Abscess","Hypervirulent"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T23:24:24.729041Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}