{"doi":"10.1128/iai.00301-21","title":"Class B Scavenger Receptors BI and BII Protect against LPS-Induced Acute Lung Injury in Mice by Mediating LPS","abstract":"Recent studies suggest an anti-inflammatory protective role for class B scavenger receptor BI (SR-BI) in endotoxin-induced inflammation and sepsis. Other data, including ours, provide evidence for an alternative role of SR-BI, facilitating bacterial and endotoxin uptake and contributing to inflammation and bacterial infection. Enhanced endotoxin susceptibility of SR-BI-deficient mice due to their anti-inflammatory glucocorticoid deficiency complicates the understanding of SR-BI's role in endotoxemia/sepsis, calling for the use of alternative models. In this study, using human SR-BI (hSR-BI) and hSR-BII transgenic mice, we found that SR-BI and, to a lesser extent, its splicing variant SR-BII protect against LPS-induced lung damage. At 20 h after intratracheal LPS instillation, the extent of pulmonary inflammation and vascular leakage was significantly lower in hSR-BI and hSR-BII transgenic mice than in wild-type mice. Higher bronchoalveolar lavage fluid (BALF) inflammatory cell count and protein content and lung tissue neutrophil infiltration found in wild-type mice were associated with markedly (2 to 3 times) increased proinflammatory cytokine production compared to these parameters in transgenic mice following LPS administration. The markedly lower endotoxin levels detected in BALF of transgenic versus wild-type mice and the significantly increased BODIPY-LPS uptake observed in lungs of hSR-BI and hSR-BII mice 20 h after the i.t. LPS injection suggest that hSR-BI- and hSR-BII-mediated enhanced LPS clearance in the airways could represent the mechanism of their protective role against LPS-induced acute lung injury.","journal":"Infection and Immunity","year":2021,"id":184456,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9447,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":534771,"name":"Alexander V. Bocharov","orcid":"0000-0002-3482-2980","position":1,"is_corresponding":false},{"id":535622,"name":"Tatyana G. Vishnyakova","orcid":null,"position":2,"is_corresponding":false},{"id":534773,"name":"Zhigang Chen","orcid":"0000-0002-0797-7215","position":3,"is_corresponding":false},{"id":414581,"name":"Anna A. Birukova","orcid":"0000-0003-0535-7693","position":4,"is_corresponding":false},{"id":414575,"name":"Yunbo Ke","orcid":"0000-0002-4151-9058","position":5,"is_corresponding":false},{"id":592660,"name":"Xuzhen Hu","orcid":null,"position":6,"is_corresponding":false},{"id":740366,"name":"Peter S. T. Yuen","orcid":null,"position":7,"is_corresponding":false},{"id":461361,"name":"Robert A. Star","orcid":"0000-0003-0940-3079","position":8,"is_corresponding":false},{"id":414580,"name":"Konstantin G. Birukov","orcid":"0000-0002-0303-5394","position":9,"is_corresponding":false},{"id":535625,"name":"Amy P. Patterson","orcid":null,"position":10,"is_corresponding":false},{"id":535624,"name":"Thomas L. Eggerman","orcid":null,"position":11,"is_corresponding":false},{"id":534772,"name":"Irina N. Baranova","orcid":"0000-0003-4250-1340","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-18T23:48:30.970730Z","pmid":"34097506","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}