{"doi":"10.1128/ec.00240-09","title":"Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by\n            <i>Cryptococcus neoformans</i>","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            <jats:italic>Cryptococcus neoformans</jats:italic>\n            cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.\n          </jats:p>","journal":"Eukaryotic Cell","year":2009,"id":595112,"datarank":0.7266280629687888,"base_score":4.844187086458591,"endowment":4.844187086458591,"self_citation_contribution":0.7266280629687888,"citation_network_contribution":0.0,"self_endowment_contribution":0.7266280629687888,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":126,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1523734,"name":"Babette Weksler","orcid":null,"position":1,"is_corresponding":false},{"id":1155877,"name":"Ignacio Romero","orcid":"0000-0003-0364-6969","position":2,"is_corresponding":false},{"id":1523735,"name":"Pierre-Olivier Couraud","orcid":null,"position":3,"is_corresponding":false},{"id":935693,"name":"Angie Gelli","orcid":"0000-0003-3351-0683","position":4,"is_corresponding":false},{"id":936336,"name":"Kiem Vu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by <i>Cryptococcus neoformans</i>","abstract":"Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.","is_dataset_classified":null,"base_score":4.844187086458591,"endowment":4.844187086458591,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19767445","pmcid":"PMC2772405","openalex_id":"https://openalex.org/W2116304792","authors":[],"funders":[],"total_grants":0,"fwci":3.6205,"citation_percentile":0.93256748,"influential_citations":0,"citation_trend":[{"year":2012,"count":10},{"year":2013,"count":9},{"year":2014,"count":6},{"year":2015,"count":6},{"year":2016,"count":7},{"year":2017,"count":11},{"year":2018,"count":2},{"year":2019,"count":10},{"year":2020,"count":8},{"year":2021,"count":7},{"year":2022,"count":7},{"year":2023,"count":11},{"year":2024,"count":12},{"year":2025,"count":6},{"year":2026,"count":4}],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://doi.org/10.1128/ec.00240-09","host_type":"journal"},{"url":"https://doi.org/10.1128/ec.00240-09","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19767445","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2772405","host_type":"repository"}],"fields_of_study":["Fungal Infections and Studies","Antifungal resistance and susceptibility","Cytomegalovirus and herpesvirus research"],"mesh_terms":["Blood-Brain Barrier","Brain","Cell Line","Central Nervous System Infections","Cryptococcosis","Cryptococcus neoformans","Humans","Models, Biological","Gene Expression","Endothelial Cells"],"keywords":["Cryptococcus neoformans","Blood–brain barrier","Central nervous system","Biology","Endothelial stem cell","Immortalised cell line","In vitro","Cell culture","Nervous system","Immunology","Cell biology","Microbiology","Neuroscience","Biochemistry","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T16:38:16.412687Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}