{"doi":"10.1128/cmr.8.2.293","title":"Virus receptors: implications for pathogenesis and the design of antiviral agents","abstract":"<jats:p>A virus initiates infection by attaching to its specific receptor on the surface of a susceptible host cell. This prepares the way for the virus to enter the cell. Consequently, the expression of the receptor on specific cells and tissues of the host is a major determinant of the route of entry of the virus into the host and of the patterns of virus spread and pathogenesis in the host. This review emphasizes the virus-receptor interactions of human immunodeficiency virus, the rhinoviruses, the herpesviruses, and the coronaviruses. These interactions are often found to be complex and dynamic, involving multiple sites or factors on both the virus and the host cell. Also, the receptor may play an important role in virus entry per se in addition to its role in virus binding. In the cases of human immunodeficiency virus and the rhinoviruses, ingenious approaches to therapeutic strategies based on inhibiting virus attachment and entry are under development and in clinical trials.</jats:p>","journal":"Clinical Microbiology Reviews","year":1995,"id":19909,"datarank":7.231245035623186,"base_score":4.248495242049359,"endowment":4.248495242049359,"self_citation_contribution":0.637274286307404,"citation_network_contribution":6.5939707493157815,"self_endowment_contribution":0.637274286307404,"citer_contribution":6.5939707493157815,"corpus_percentile":null,"corpus_rank":null,"citation_count":69,"citer_count":63,"citers_with_citation_signal":51,"citers_with_endowment":51,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":133370,"name":"L C Norkin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.248495242049359,"endowment":4.248495242049359,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7621403","pmcid":"PMC172860","openalex_id":"https://openalex.org/W2102320035","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"CA50532","title":null}],"total_grants":1,"fwci":2.3399,"citation_percentile":0.89568733,"influential_citations":2,"citation_trend":[{"year":2013,"count":2},{"year":2014,"count":3},{"year":2015,"count":2},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2025,"count":3}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://cmr.asm.org/content/cmr/8/2/293.full.pdf","host_type":"journal"},{"url":"https://doi.org/10.1128/cmr.8.2.293-315.1995","host_type":"GREEN"},{"url":"https://cmr.asm.org/content/cmr/8/2/293.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/CMR.8.2.293","host_type":"publisher"},{"url":"https://doi.org/10.1128/cmr.8.2.293","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7621403","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/172860","host_type":"repository"}],"fields_of_study":["Immune Response and Inflammation","Immune Cell Function and Interaction","Viral Infections and Immunology Research","Medicine","Biology","Antiviral Agents","CD4 Antigens","Coronavirus","Drug Design","HIV","Herpesviridae","Humans","Intercellular Adhesion Molecule-1","Models, Molecular","Picornaviridae","Receptors, Virus","Retroviridae"],"mesh_terms":["Antiviral Agents","Herpesviridae","HIV","Humans","Models, Molecular","Picornaviridae","Receptors, Virus","Retroviridae","Drug Design","CD4 Antigens","Coronavirus","Intercellular Adhesion Molecule-1"],"keywords":["Virus","Virology","Biology","Viral entry","Receptor","Pathogenesis","Antibody-dependent enhancement","Host (biology)","Viral pathogenesis","Viral replication","Immunology","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-04T06:14:31.124816Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}